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Serum Bone Resorption Markers after Parathyroidectomy for Renal Hyperparathyroidism: Correlation Analyses for the Cross-Linked N-telopeptide of Collagen I and Tartrate-Resistant Acid Phosphatase
- Source :
- The Scientific World Journal, Vol 2012 (2012), The Scientific World Journal
- Publication Year :
- 2012
- Publisher :
- Hindawi Limited, 2012.
-
Abstract
- Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT) with increased serum concentrations of bone resorption markers such as the cross-linked N-telopeptide of type I collagen (NTX) and type-5b tartrate-resistant acid phosphatase (TRAP). When SHPT proves refractory to treatment, parathyroidectomy (PTX) may be needed. Renal patients on maintenance HD who received PTX for refractory SHPT (n=23) or who did not develop refractory SHPT (control subjects;n=25) were followed prospectively for 4 weeks. Serum intact parathyroid hormone (iPTH), NTX, TRAP, and bone alkaline phosphatase (BAP) concentrations were measured serially and correlation analyses were performed. iPTH values decreased rapidly and dramatically. BAP values increased progressively with peak increases observed at 2 weeks after surgery. NTX and TRAP values decreased concurrently and progressively through 4 weeks following PTX. A significant correlation between TRAP and NTX values was observed before PTX but not at 4 weeks after PTX. Additionally, the fractional changes in serum TRAP were larger than those in serum NTX at all times examined after PTX. Serum iPTH, TRAP, and NTX values declined rapidly following PTX for SHPT. Serum TRAP values declined to greater degrees than serum NTX values throughout the 4-week period following PTX.
- Subjects :
- Parathyroidectomy
medicine.medical_specialty
endocrine system
Article Subject
medicine.medical_treatment
Acid Phosphatase
lcsh:Medicine
lcsh:Technology
General Biochemistry, Genetics and Molecular Biology
Bone resorption
Collagen Type I
N-terminal telopeptide
Internal medicine
medicine
Humans
Bone Resorption
lcsh:Science
General Environmental Science
Tartrate-resistant acid phosphatase
Hyperparathyroidism
biology
Chemistry
Tartrate-Resistant Acid Phosphatase
lcsh:T
lcsh:R
Acid phosphatase
General Medicine
medicine.disease
Isoenzymes
Endocrinology
biology.protein
Clinical Study
Secondary hyperparathyroidism
Kidney Diseases
lcsh:Q
Peptides
human activities
Type I collagen
Biomarkers
Subjects
Details
- Language :
- English
- Volume :
- 2012
- Database :
- OpenAIRE
- Journal :
- The Scientific World Journal
- Accession number :
- edsair.doi.dedup.....7b640d214271f96413f06e8fe813ebc0