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Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism
- Source :
- International Journal of Epidemiology
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- BackgroundMounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.MethodsWe review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays.ResultsWe summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review.ConclusionsMany studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health.
- Subjects :
- 0301 basic medicine
Candidate gene
Epidemiology
Offspring
growth
Developmental Origins of Health and Disease
Computational biology
Biology
Epigenesis, Genetic
03 medical and health sciences
Pregnancy
Humans
Epigenetics
Gene
metastable epialleles
DNA methylation
Maternal Nutritional Physiological Phenomena
Nutrients
General Medicine
Epigenome
one-carbon metabolism
Carbon
Diet
fetal programming
030104 developmental biology
Gene Expression Regulation
cardiometabolic outcomes
Female
candidate genes
Candidate Disease Gene
Genomic imprinting
cognitive development
Subjects
Details
- ISSN :
- 14643685 and 03005771
- Database :
- OpenAIRE
- Journal :
- International Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....7b6452823f9c9c2d2c806579f07a519f