PCSK9 Involvement in Aortic Valve Calcification

Authors :: Silvia S. Barbieri
Benoit J. Arsenault
Paolo Poggio
Paola Songia
Marina Camera
Vincenza Valerio
Nicola Ferri
Ilaria Zanotti
Romain Capoulade
Laura Cavallotti
Source :: Journal of the American College of Cardiology. 72:3225-3227
Publication Year :: 2018
Publisher :: Elsevier BV, 2018.
Abstract: High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) (>305 ng/ml) have been recently associated, along with insulin resistance and lipoprotein-associated phospholipase A2 activity, with aortic bioprosthesis calcification and able to predict hemodynamic valve deterioration [(1)][1].

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