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Continuous oestrogen-progestogen treatment and bone metabolism in post-menopausal women
- Source :
- Maturitas. 10:51-58
- Publication Year :
- 1988
- Publisher :
- Elsevier BV, 1988.
-
Abstract
- The suggestion that norethisterone acetate (NETA) stimulates bone formation prompted us to investigate calcium and bone metabolism in post-menopausal women treated with a continuous combination of oestrogen and NETA. The study included 49 healthy post-menopausal women. After an initial examination the women were randomly allocated to 2 yr of treatment with either hormones or placebo; 43 women completed the study. Within the first year of treatment the hormone group showed a slight, but significant, increase in bone mineral content in the forearms (single photon absorptiometry) and in the total skeleton (dual photon absorptiometry). After this initial increase the bone mass remained constant throughout the trial. Bone mineral density of the spine (dual photon absorptiometry) showed a significant increase of more than 5% in the hormone group. There were significant decreases of 4-7% in bone mass in the placebo group over 2 yr. Biochemical estimates of bone turnover (plasma bone Gla protein, serum alkaline phosphatase, fasting urinary calcium and fasting urinary hydroxyproline) fell significantly in the hormone group, but remained unchanged in the placebo group. We conclude that continuous administration of NETA in combination with oestrogen provides effective prophylaxis against post-menopausal bone loss, although it does not produce a persistent positive calcium balance in early post-menopausal women.
- Subjects :
- medicine.medical_specialty
Biochemical Phenomena
Osteocalcin
Osteoporosis
Placebo
Biochemistry
Bone and Bones
General Biochemistry, Genetics and Molecular Biology
Bone remodeling
Random Allocation
Double-Blind Method
Internal medicine
medicine
Humans
Radionuclide Imaging
Bone mineral
Clinical Trials as Topic
Minerals
Estradiol
biology
business.industry
Calcium-Binding Proteins
Obstetrics and Gynecology
Middle Aged
Alkaline Phosphatase
medicine.disease
Norethisterone acetate
Urinary calcium
Menopause
Drug Combinations
Hydroxyproline
Norethindrone Acetate
Endocrinology
Creatinine
biology.protein
Calcium
Female
Norethindrone
business
medicine.drug
Subjects
Details
- ISSN :
- 03785122
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Maturitas
- Accession number :
- edsair.doi.dedup.....7b6d8a7de6c4bc19efa0b5845ee6e9e7
- Full Text :
- https://doi.org/10.1016/0378-5122(88)90131-4