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Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure
Authors :
Karl Swedberg James B. Young Inder S. Anand Sunfa Cheng Akshay S. Desai Rafael Diaz Aldo P. Maggioni John J. V. McMurray Christopher O'Connor Marc A. Pfeffer Scott D. Solomon Yan Sun Michal Tendera Dirk J. van Veldhuisen Young J Grinfeld L Krum H Vanhaecke J Olivera Clausell N Goudev A Howlett J Corbalan R Hradec J Kober L Eha J Cohen Solal A Anker SD Chopra V Lewis B Erglis A Sakalyte G Cardona Munoz E Dunselman P Dickstein K Ponikowski P Seabra Gomes R Apetrei E Mareev V Murin J Dalby A Lopez Sendon J Willenheimer R Cleland J Adams K Anand I Butler J Dunlap M Felker M Ghali J Levy W Carson P Cohn J Drexler H Pocock S Ryden L Poole Wilson P Fishbane S Ivanovich P Nissenson A Katz S Barkoudah E Campbell P Desai A Finn PV Hartley L Kasabov R Odutayo KA Rajesh V Solomon S Weinrauch LA Albizem M Cheng S Chou W Deegenaars M Dougherty M Fouqueray B Froissart M Froment A Gadd S Ghosh S Grazette L Guillet S Gulabani D Haddock B Harris C Jaffer A Kerns C Kim J Knussel B Law H Mather R Mix C Moore L Moyes R Polu K Rossert J Scarlata D Smirnakis K Smith L Snyder W Sun Y Trotman ML Wasserman S Watkins A Wong M Zhang Y Amuchastegui M Belziti C Bluguermann J Caccavo M Cartasegna L Colque R Cuneo C Fernandez A Gabito A Goicochea R Gonzalez M Gorosito V Hominal M Kevorkian R Litvak Bruno M Llanos J Mackinnon I Manuale O Marzetti E Nul D Perna E Riccitelli M Sanchez A Santos D Schygiel P Toblli J Vogel D Aggarwal A Amerena J De Looze F Fletcher P Hare D Ireland M Lattimore J Marwick T Sindone A Thompson P Waites J Altenberger J Ebner C Lenz K Pacher R Poelzl G Charlier F de Ceuninck M De Keulenaer G Dendale P Maréchal P Mullens W Thoeng J Vanderheyden M Weytjens C Wollaert B Albuquerque D Almeida D Aspe y. Rosas J Bocchi E Bordignon S Clausell N Kaiser S Leaes P Martins Alves S Montera M Moura L Pereira de Castro R Rassi S Reis A Saraiva J Simões M Souza Neto J Teixeira M Benov H Chompalova B Donova T Georgiev P Gotchev D Grigorov M Guenova D Hergeldjieva V Ivanov D Kostova E Manolova A Marchev S Nikolov F Popov A Raev D Tzekova M Czarnecki W Giannetti N Haddad H Heath J Huynh T Lepage S Liu P Lonn E Ma P Manyari D Moe G Parker J Pesant Y Rajda M Ricci J Roth S Sestier F Sluzar V Sussex B Vizel S Antezana G Bugueno C Castro P Conejeros C Manriquez L Martinez D Potthoff S Stockins B Vukasovic J Gregor P Herold M Jerabek O Jirmar R Kuchar R Linhart A Podzemska B Soucek M Spac J Spacek R Vodnansky P Bronnum Schou J Clemmensen K Egstrup K Jensen G Kjoller Hansen L Markenvard J Rokkedal J Skagen K Torp Pedersen C Tuxen C Videbak L Laks T Vahula V Harjola V Kettunen R Kotila M Bauer F Coisne D Davy J De Groote P Dos Santos P Funck F Galinier M Gibelin P Isnard R Neuder Y Roul G Sabatier R Trochu J Denny S Dreykluft T Flesch M Genth Zotz S Hambrecht R Hein J Jeserich M John M Kreider Stempfle H Laufs U Muellerleile K Natour M Sandri M Schäufele T von Hodenberg E Weyland K Winkelmann B Tse H Yan B Barsi B Csikasz J Dezsi C Edes I Forster T Karpati P Kerekes C Kis E Kosa I Lupkovics G Nagy A Preda I Ronaszeki A Tomcsanyi J Zamolyi K Agarwal D Bahl V Bordoloi A Chockalingam K Chopda M Dugal J Ghaisas N Grant P Hiremath S Iyengar S Jagadeesa Subramania B Jain P Joshi A Khan A Mullasari A Naik S Oomman A Pai V Pareppally Gopal R Parikh K Patel T Prakash V Sastry B Sathe S Sinha N Srikanthan V Subburamakrishnan P Thacker H Wander G Admon D Katz A Klainman E Marmor A Moriel M Mosseri M Shotan A Weinstein J Zimlichman R Agostoni P Albanese M Alunni G Bini R Boccanelli A Bolognese L Campana C Carbonieri E Carpino C Checco L Cosmi F Angelo GD De Cristofaro M Floresta A Fucili A Galvani M Ivleva A Marra S Musca G Peccerillo N Picchio E Russo T Scelsi L Senni M Tavazzi L Jasinkevica I Kakurina N Veze I Volans E Bagdonas A Berukstis E Celutkiene J Dambrauskaite A Jarasuniene D Luksiene D Rudys A Sliaziene S Aguilar Romero R Cardona Muñoz E Castro Jimenez J Chavez Herrera J Chuquiure Valenzuela E De la Pena G Herrera E Leiva Pons J Lopez Alvarado A Mendez Machado G Ramos Lopez G Basart D Buijs E Cornel J de Leeuw M Dijkgraaf R Freericks M Hamraoui K Lenderlink T Linssen G Lodewick P Lodewijks C Lok D Nierop P Ronner E Somsen A van Dantzig J van der Burgh P van Kempen L van Vlies B Voors A Wardeh A Willems F Gundersen T Hole T Thalamus J Westheim A Dabrowski M Gorski J Korewicki J Kuc K Miekus P Musial W Niegowska J Piotrowski W Podolec P Polonski L Rynkiewicz A Szelemej R Trusz Gluza M Ujda M Wojciechowski D Wysokinski A Camacho A Fonseca C Monteiro P Bruckner I Carasca E Coman I Datcu M Dragulescu S Ionescu P Iordachescu Petica D Manitiu I Popa V Pop Moldovan A Radoi M Stamate S Tomescu M Vita I Aroutiounov G Ballyuzek M Bart B Churina S Glezer M Goloshchekin B Kobalava Z Kostenko V Lopatin Y Martynov A Orlov V Semernin E Shogenov Z Sidorenko B Skvortsov A Storzhakov G Sulimov V Talibov O Tereshenko S Tsyrline V Zadionchenko V Zateyshchikov D Dzupina A Hranai M Kmec J Micko K Pella D Sojka G Spisak V Vahala P Vinanska D Badat A Bayat J Dawood S Delport E Ellis G Garda R Klug E Mabin T Naidoo D Pretorius M Ranjith N Van Zyl L Weich H Anguita M Berrazueta J Bruguera i. Cortada J de Teresa E Gómez Sánchez M González Juanatey J Gonzalez Maqueda I Jordana R Lupon J Manzano L Pascual Figal D Pulpón L Recio J Ridocci Soriano F Rodríguez Lambert J Roig Minguell E Romero J Valdovinos P Klintberg L Kronvall T Lycksell M Morner S Rydberg E Swedberg K Timberg I Wikstrom G Moccetti T Ashok J Banerjee P Carr White G Connolly E Francis M Greenbaum R Kadr H Lindsay S McMurray J Megarry S Memon A Murdoch D Senior R Squire I Tan L Witte K Adamson P Adler A Altschul L Altschuller A Amirani H Andreou C Ansari M Antonishen M Banchs H Banerjee S Banish D Bank A Barbagelata A Barnard D Bellinger R Benn A Berk M Berry B Bethala V Bilazarian S Bisognano J Bleyer F Blum M Boehmer J Bouchard A Boyle A Bozkurt B Brown C Burlew B Burnham K Call J Cambier P Cappola T Carlson R Chandler B Chandra R Chandraratna P Chernick R Colan D Colfer H Colucci W Connelly T Costantini O Dadkhah S Dauber I Davis J Davis S Denning S Drazner M Dunlap S Egbujiobi L Elkayam U Elliott J El Shahawy M Essandoh L Ewald G Fang J Farhoud H Felker G Fernandez J Festin R Fishbein G Florea V Flores E Floro J Gabris M Garg M Gatewood R Geller M Ghumman W Gibbs G Gillespie E Gilmore R Gogia H Goldberg L Gradus Pizlo I Grainger T Gudmundsson G Gunawardena D Gupta D Hack T Hall S Hamroff G Hankins S Hanna M Hargrove J Haught W Hauptman P Hazelrigg M Herzog C Heywood J Hill T Hilton T Hirsch H Hunter J Ibrahim H Imburgia M Iteld B Jackson B Jaffrani N Jain D Jain A James M Jimenez J Johnson E Kale P Kaneshige A Kapadia S Karia D Karlsberg R Katholi R Kerut E Khoury W Kipperman R Klapholz M Kosinski E Kozinn M Kraus D Krueger S Kumar S Lader E Lee C Lewis E Light McGroary K Loh I Lombardi W Machado C Maislos F Mancini D Markus T Mather P McCants K McGrew F McLaurin B McMillan E McNamara D Meyer T Meymandi S Miller A Minami E Modi M Mody F Mohanty P Moscoso R Moskowitz R Moustafa M Mullen M Naz T Noonan T O. Brien T Oellerich W Oren R Pamboukian S Pereira N Pitt W Porter C Prabhu S Promisloff S Ratkovec R Richardson R Ross A Saleh N Saltzberg M Sarkar S Schmedtje J Schneider R Schuyler G Shanes J Sharma A Siegel C Siegel R Silber D Singh N Singh J Singh V Sklar J Small R Smith A Smith E Smull D Sotolongo R Staniloae C Stapleton D Steele P Stehlik J Stein M Tang W Thadani U Torre Amoine G Trichon B Tsai C Tummala R Van Bakel A Vicari R Vijay N Vijayaraghavan K Vittorio T Vossler M Wagoner L Wallis D Ward N Widmer M Wight J Wilkins C Williams C Williams G Winchester M Winkel E Wittmer B Wood D Wormer D Wright R Xu Z Yasin M Zolty R. PERRONE FILARDI, PASQUALE Karl, Swedberg James B., Young Inder S., Anand Sunfa, Cheng Akshay S., Desai Rafael, Diaz Aldo P., Maggioni John J. V., Mcmurray Christopher, O'Connor Marc A., Pfeffer Scott D., Solomon Yan, Sun Michal, Tendera Dirk J., van Veldhuisen Young, J Grinfeld, L Krum, H Vanhaecke, J Olivera Clausell, N Goudev, A Howlett, J Corbalan, R Hradec, J Kober, L Eha, J Cohen Solal, A Anker, Sd Chopra, V Lewis, B Erglis, A Sakalyte, G Cardona Munoz, E Dunselman, P Dickstein, K Ponikowski, P Seabra Gomes, R Apetrei, E Mareev, V Murin, J Dalby, A Lopez Sendon, J Willenheimer, R Cleland, J Adams, K Anand, I Butler, J Dunlap, M Felker, M Ghali, J Levy, W Carson, P Cohn, J Drexler, H Pocock, S Ryden, L Poole Wilson, P Fishbane, S Ivanovich, P Nissenson, A Katz, S Barkoudah, E Campbell, P Desai, A Finn, Pv Hartley, L Kasabov, R Odutayo, Ka Rajesh, V Solomon, S Weinrauch, La Albizem, M Cheng, S Chou, W Deegenaars, M Dougherty, M Fouqueray, B Froissart, M Froment, A Gadd, S Ghosh, S Grazette, L Guillet, S Gulabani, D Haddock, B Harris, C Jaffer, A Kerns, C Kim, J Knussel, B Law, H Mather, R Mix, C Moore, L Moyes, R Polu, K Rossert, J Scarlata, D Smirnakis, K Smith, L Snyder, W Sun, Y Trotman, Ml Wasserman, S Watkins, A Wong, M Zhang, Y Amuchastegui, M Belziti, C Bluguermann, J Caccavo, M Cartasegna, L Colque, R Cuneo, C Fernandez, A Gabito, A Goicochea, R Gonzalez, M Gorosito, V Hominal, M Kevorkian, R Litvak Bruno, M Llanos, J Mackinnon, I Manuale, O Marzetti, E Nul, D Perna, E Riccitelli, M Sanchez, A Santos, D Schygiel, P Toblli, J Vogel, D Aggarwal, A Amerena, J De Looze, F Fletcher, P Hare, D Ireland, M Lattimore, J Marwick, T Sindone, A Thompson, P Waites, J Altenberger, J Ebner, C Lenz, K Pacher, R Poelzl, G Charlier, F de Ceuninck, M De Keulenaer, G Dendale, P Maréchal, P Mullens, W Thoeng, J Vanderheyden, M Weytjens, C Wollaert, B Albuquerque, D Almeida, D Aspe y., Rosas J Bocchi, E Bordignon, S Clausell, N Kaiser, S Leaes, P Martins Alves, S Montera, M Moura, L Pereira de Castro, R Rassi, S Reis, A Saraiva, J Simões, M Souza Neto, J Teixeira, M Benov, H Chompalova, B Donova, T Georgiev, P Gotchev, D Grigorov, M Guenova, D Hergeldjieva, V Ivanov, D Kostova, E Manolova, A Marchev, S Nikolov, F Popov, A Raev, D Tzekova, M Czarnecki, W Giannetti, N Haddad, H Heath, J Huynh, T Lepage, S Liu, P Lonn, E Ma, P Manyari, D Moe, G Parker, J Pesant, Y Rajda, M Ricci, J Roth, S Sestier, F Sluzar, V Sussex, B Vizel, S Antezana, G Bugueno, C Castro, P Conejeros, C Manriquez, L Martinez, D Potthoff, S Stockins, B Vukasovic, J Gregor, P Herold, M Jerabek, O Jirmar, R Kuchar, R Linhart, A Podzemska, B Soucek, M Spac, J Spacek, R Vodnansky, P Bronnum Schou, J Clemmensen, K Egstrup, K Jensen, G Kjoller Hansen, L Markenvard, J Rokkedal, J Skagen, K Torp Pedersen, C Tuxen, C Videbak, L Laks, T Vahula, V Harjola, V Kettunen, R Kotila, M Bauer, F Coisne, D Davy, J De Groote, P Dos Santos, P Funck, F Galinier, M Gibelin, P Isnard, R Neuder, Y Roul, G Sabatier, R Trochu, J Denny, S Dreykluft, T Flesch, M Genth Zotz, S Hambrecht, R Hein, J Jeserich, M John, M Kreider Stempfle, H Laufs, U Muellerleile, K Natour, M Sandri, M Schäufele, T von Hodenberg, E Weyland, K Winkelmann, B Tse, H Yan, B Barsi, B Csikasz, J Dezsi, C Edes, I Forster, T Karpati, P Kerekes, C Kis, E Kosa, I Lupkovics, G Nagy, A Preda, I Ronaszeki, A Tomcsanyi, J Zamolyi, K Agarwal, D Bahl, V Bordoloi, A Chockalingam, K Chopda, M Dugal, J Ghaisas, N Grant, P Hiremath, S Iyengar, S Jagadeesa Subramania, B Jain, P Joshi, A Khan, A Mullasari, A Naik, S Oomman, A Pai, V Pareppally Gopal, R Parikh, K Patel, T Prakash, V Sastry, B Sathe, S Sinha, N Srikanthan, V Subburamakrishnan, P Thacker, H Wander, G Admon, D Katz, A Klainman, E Marmor, A Moriel, M Mosseri, M Shotan, A Weinstein, J Zimlichman, R Agostoni, P Albanese, M Alunni, G Bini, R Boccanelli, A Bolognese, L Campana, C Carbonieri, E Carpino, C Checco, L Cosmi, F Angelo, Gd De Cristofaro, M Floresta, A Fucili, A Galvani, M Ivleva, A Marra, S Musca, G Peccerillo, N PERRONE FILARDI, Pasquale Picchio, E Russo, T Scelsi, L Senni, M Tavazzi, L Jasinkevica, I Kakurina, N Veze, I Volans, E Bagdonas, A Berukstis, E Celutkiene, J Dambrauskaite, A Jarasuniene, D Luksiene, D Rudys, A Sliaziene, S Aguilar Romero, R Cardona Muñoz, E Castro Jimenez, J Chavez Herrera, J Chuquiure Valenzuela, E De la Pena, G Herrera, E Leiva Pons, J Lopez Alvarado, A Mendez Machado, G Ramos Lopez, G Basart, D Buijs, E Cornel, J de Leeuw, M Dijkgraaf, R Freericks, M Hamraoui, K Lenderlink, T Linssen, G Lodewick, P Lodewijks, C Lok, D Nierop, P Ronner, E Somsen, A van Dantzig, J van der Burgh, P van Kempen, L van Vlies, B Voors, A Wardeh, A Willems, F Gundersen, T Hole, T Thalamus, J Westheim, A Dabrowski, M Gorski, J Korewicki, J Kuc, K Miekus, P Musial, W Niegowska, J Piotrowski, W Podolec, P Polonski, L Rynkiewicz, A Szelemej, R Trusz Gluza, M Ujda, M Wojciechowski, D Wysokinski, A Camacho, A Fonseca, C Monteiro, P Bruckner, I Carasca, E Coman, I Datcu, M Dragulescu, S Ionescu, P Iordachescu Petica, D Manitiu, I Popa, V Pop Moldovan, A Radoi, M Stamate, S Tomescu, M Vita, I Aroutiounov, G Ballyuzek, M Bart, B Churina, S Glezer, M Goloshchekin, B Kobalava, Z Kostenko, V Lopatin, Y Martynov, A Orlov, V Semernin, E Shogenov, Z Sidorenko, B Skvortsov, A Storzhakov, G Sulimov, V Talibov, O Tereshenko, S Tsyrline, V Zadionchenko, V Zateyshchikov, D Dzupina, A Hranai, M Kmec, J Micko, K Pella, D Sojka, G Spisak, V Vahala, P Vinanska, D Badat, A Bayat, J Dawood, S Delport, E Ellis, G Garda, R Klug, E Mabin, T Naidoo, D Pretorius, M Ranjith, N Van Zyl, L Weich, H Anguita, M Berrazueta, J Bruguera i., Cortada J de Teresa, E Gómez Sánchez, M González Juanatey, J Gonzalez Maqueda, I Jordana, R Lupon, J Manzano, L Pascual Figal, D Pulpón, L Recio, J Ridocci Soriano, F Rodríguez Lambert, J Roig Minguell, E Romero, J Valdovinos, P Klintberg, L Kronvall, T Lycksell, M Morner, S Rydberg, E Swedberg, K Timberg, I Wikstrom, G Moccetti, T Ashok, J Banerjee, P Carr White, G Connolly, E Francis, M Greenbaum, R Kadr, H Lindsay, S Mcmurray, J Megarry, S Memon, A Murdoch, D Senior, R Squire, I Tan, L Witte, K Adamson, P Adler, A Altschul, L Altschuller, A Amirani, H Andreou, C Ansari, M Antonishen, M Banchs, H Banerjee, S Banish, D Bank, A Barbagelata, A Barnard, D Bellinger, R Benn, A Berk, M Berry, B Bethala, V Bilazarian, S Bisognano, J Bleyer, F Blum, M Boehmer, J Bouchard, A Boyle, A Bozkurt, B Brown, C Burlew, B Burnham, K Call, J Cambier, P Cappola, T Carlson, R Chandler, B Chandra, R Chandraratna, P Chernick, R Colan, D Colfer, H Colucci, W Connelly, T Costantini, O Dadkhah, S Dauber, I Davis, J Davis, S Denning, S Drazner, M Dunlap, S Egbujiobi, L Elkayam, U Elliott, J El Shahawy, M Essandoh, L Ewald, G Fang, J Farhoud, H Felker, G Fernandez, J Festin, R Fishbein, G Florea, V Flores, E Floro, J Gabris, M Garg, M Gatewood, R Geller, M Ghumman, W Gibbs, G Gillespie, E Gilmore, R Gogia, H Goldberg, L Gradus Pizlo, I Grainger, T Gudmundsson, G Gunawardena, D Gupta, D Hack, T Hall, S Hamroff, G Hankins, S Hanna, M Hargrove, J Haught, W Hauptman, P Hazelrigg, M Herzog, C Heywood, J Hill, T Hilton, T Hirsch, H Hunter, J Ibrahim, H Imburgia, M Iteld, B Jackson, B Jaffrani, N Jain, D Jain, A James, M Jimenez, J Johnson, E Kale, P Kaneshige, A Kapadia, S Karia, D Karlsberg, R Katholi, R Kerut, E Khoury, W Kipperman, R Klapholz, M Kosinski, E Kozinn, M Kraus, D Krueger, S Kumar, S Lader, E Lee, C Lewis, E Light McGroary, K Loh, I Lombardi, W Machado, C Maislos, F Mancini, D Markus, T Mather, P Mccants, K Mcgrew, F Mclaurin, B Mcmillan, E Mcnamara, D Meyer, T Meymandi, S Miller, A Minami, E Modi, M Mody, F Mohanty, P Moscoso, R Moskowitz, R Moustafa, M Mullen, M Naz, T Noonan, T O., Brien T Oellerich, W Oren, R Pamboukian, S Pereira, N Pitt, W Porter, C Prabhu, S Promisloff, S Ratkovec, R Richardson, R Ross, A Saleh, N Saltzberg, M Sarkar, S Schmedtje, J Schneider, R Schuyler, G Shanes, J Sharma, A Siegel, C Siegel, R Silber, D Singh, N Singh, J Singh, V Sklar, J Small, R Smith, A Smith, E Smull, D Sotolongo, R Staniloae, C Stapleton, D Steele, P Stehlik, J Stein, M Tang, W Thadani, U Torre Amoine, G Trichon, B Tsai, C Tummala, R Van Bakel, A Vicari, R Vijay, N Vijayaraghavan, K Vittorio, T Vossler, M Wagoner, L Wallis, D Ward, N Widmer, M Wight, J Wilkins, C Williams, C Williams, G Winchester, M Winkel, E Wittmer, B Wood, D Wormer, D Wright, R Xu, Z Yasin, M Zolty, R. Faculteit Medische Wetenschappen/UMCG Cardiovascular Centre (CVC)
Source :
CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET, New England Journal of Medicine, 368(13), 1210-1219. MASSACHUSETTS MEDICAL SOC
Publication Year :
2013
Abstract
BACKGROUND: Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia. METHODS: In this randomized, double-blind trial, we assigned 2278 patients with systolic heart failure and mild-to-moderate anemia (hemoglobin level, 9.0 to 12.0 g per deciliter) to receive either darbepoetin alfa (to achieve a hemoglobin target of 13 g per deciliter) or placebo. The primary outcome was a composite of death from any cause or hospitalization for worsening heart failure. RESULTS: The primary outcome occurred in 576 of 1136 patients (50.7%) in the darbepoetin alfa group and 565 of 1142 patients (49.5%) in the placebo group (hazard ratio in the darbepoetin alfa group, 1.01; 95% confidence interval, 0.90 to 1.13; P=0.87). There was no significant between-group difference in any of the secondary outcomes. The neutral effect of darbepoetin alfa was consistent across all prespecified subgroups. Fatal or nonfatal stroke occurred in 42 patients (3.7%) in the darbepoetin alfa group and 31 patients (2.7%) in the placebo group (P=0.23). Thromboembolic adverse events were reported in 153 patients (13.5%) in the darbepoetin alfa group and 114 patients (10.0%) in the placebo group (P=0.01). Cancer-related adverse events were similar in the two study groups. CONCLUSIONS: Treatment with darbepoetin alfa did not improve clinical outcomes in patients with systolic heart failure and mild-to-moderate anemia. Our findings do not support the use of darbepoetin alfa in these patients. (Funded by Amgen; RED-HF ClinicalTrials.gov number, NCT00358215.). Fil: Swedberg, Karl. University of Gothenburg; Suecia Fil: Young, James B.. Cleveland Clinic; Estados Unidos Fil: Anand, Inder S.. University of Minnesota; Estados Unidos Fil: Cheng, Sunfa. Amgen; Estados Unidos Fil: Desai, Akshay S.. Brigham and Women’s Hospital; Estados Unidos Fil: Diaz, Rafael. Estudios Clínicos Latinoamérica; Argentina Fil: Maggioni, Aldo P.. Italian Association of Hospital Cardiologists Research Center; Italia Fil: McMurray, John J.V.. University of Glasgow; Reino Unido Fil: O’Connor, Christopher. University of Duke; Estados Unidos Fil: Pfeffer, Marc A.. Brigham and Women’s Hospital; Estados Unidos Fil: Solomon, Scott D.. Brigham and Women’s Hospital; Estados Unidos Fil: Sun, Yan. Amgen; Estados Unidos Fil: Tendera, Michal. Medical University of Silesia; Polonia Fil: van Veldhuisen, Dirk J.. University of Groningen; Países Bajos Fil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Details
Language :
English
ISSN :
00284793 and 00358215
Volume :
368
Issue :
13
Database :
OpenAIRE
Journal :
New England Journal of Medicine
Accession number :
edsair.doi.dedup.....7b95caa57a41acbc92f7ec5cf8586b04
Full Text :
https://doi.org/10.1056/nejmoa1214865