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Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC
- Source :
- Current pharmaceutical design. 25(45)
- Publication Year :
- 2019
-
Abstract
- Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. : The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.
- Subjects :
- Ischemia
mTORC1
AMP-Activated Protein Kinases
Mechanistic Target of Rapamycin Complex 1
Brain Ischemia
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Humans
Middle cerebral artery occlusion
Amino Acids
Stroke
030304 developmental biology
Cause of death
Pharmacology
0303 health sciences
business.industry
AMPK
Infarction, Middle Cerebral Artery
medicine.disease
Oxygen
Glucose
Energy sensing
Ischemic stroke
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18734286
- Volume :
- 25
- Issue :
- 45
- Database :
- OpenAIRE
- Journal :
- Current pharmaceutical design
- Accession number :
- edsair.doi.dedup.....7b9f9041519541fe7008fa199f3dedad