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Takayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease?
- Source :
- Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100124-(2021), Journal of Translational Autoimmunity
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Takayasu arteritis and primary sclerosing cholangitis are two rare disorders. The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. Conversely, the aetiology of primary sclerosing cholangitis remains elusive, even if dysimmunity seems to be one of the contributors to bile duct damage. Despite this, immunosuppressants do not alter disease course. In this paper we describe the association of these two rare disorders, with an unexpected normalization of cholestatic enzymes following steroid treatment. This might hint a novel subtype of sclerosing cholangitis with a prevalent immunebackground, or a local manifestation of Takayasu arteritis.<br />Highlights • Unusual association of two rare entities: PSC (supported by the presence of IBD) and TA. • Onset of Takayasu after PSC diagnosis. • Lack of response to UDCA and fibrates. • Improvement of liver function tests after steroid treatment. • No changes on biliary tree reported on MRCP.
- Subjects :
- Vasculitis
medicine.medical_specialty
Vasculiti
Short communication
Immunology
Takayasu arteritis
Disease
Gastroenterology
Inflammatory bowel disease
Disease course
Primary sclerosing cholangitis
Takayasu arteriti
Pathogenesis
Internal medicine
medicine
Immunology and Allergy
cardiovascular diseases
skin and connective tissue diseases
Bile duct
business.industry
Primary sclerosing cholangiti
RC581-607
medicine.disease
Phenotype
medicine.anatomical_structure
Etiology
Immunologic diseases. Allergy
business
Subjects
Details
- Language :
- English
- ISSN :
- 25899090
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Autoimmunity
- Accession number :
- edsair.doi.dedup.....7bc860b887d547649bdd5fa51932a7a3