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Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 92:1068-1071
- Publication Year :
- 2021
- Publisher :
- BMJ, 2021.
-
Abstract
- ObjectiveTo investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).MethodsWe performed a case–control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1–Q4).ResultsWe analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).ConclusionsOur findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.
- Subjects :
- Male
Risk
medicine.medical_specialty
Databases, Factual
Age dependent
030204 cardiovascular system & hematology
Logistic regression
cerebrovascular
stroke
Stroke risk
Databases
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
80 and over
medicine
Humans
Stroke
Factual
Aged
Cerebral Hemorrhage
Aged, 80 and over
business.industry
Incidence
Age Factors
Middle Aged
medicine.disease
Case-Control Studies
Female
Italy
Psychiatry and Mental health
Quartile
Multicenter study
Surgery
Alcohol intake
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1468330X and 00223050
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....7bedc72ef4759e9c4df36439a6e4b1b7