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Mathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Clinical Research Study
- Source :
- AIDS Research and Human Retroviruses, AIDS Research and Human Retroviruses, Mary Ann Liebert, 2014, 30 (9), pp.831-834. ⟨10.1089/AID.2013.0286⟩
- Publication Year :
- 2014
- Publisher :
- Mary Ann Liebert Inc, 2014.
-
Abstract
- Immunological failure is identified from the estimation of certain parameters of a mathematical model of HIV infection dynamics. This identification is supported by clinical research results from an original clinical trial. Standard clinical data were collected from infected patients starting highly active antiretroviral therapy (HAART) after just 1 month of therapy initiation and were used to carry out the model identification. The early diagnosis is shown to be consistent with patient monitoring after 6 months. Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina Fil: Moog, Claude. Centre National de la Recherche Scientifique; Francia Fil: Stan, Guy Bart. Imperial College London; Reino Unido Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina Fil: Brunet, Cecile. Universite de Nantes; Francia Fil: Raffi, Francois. Universite de Nantes; Francia Fil: Ferré, Virginie. Universite de Nantes; Francia Fil: Mhawej, Marie José. Centre National de la Recherche Scientifique; Francia Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Matematica Aplicada; Argentina Fil: Ouattara, Djomangan. Universite de Nantes; Francia Fil: Ernst, Damien. Universite de Liege; Bélgica Fil: Fonteneau, Raphael. Universite de Liege; Bélgica Fil: Xia, Xiaohua. University of Pretoria; Sudáfrica
- Subjects :
- 0209 industrial biotechnology
Pediatrics
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Anti-HIV Agents
[SDV]Life Sciences [q-bio]
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
Apoptosis
010103 numerical & computational mathematics
02 engineering and technology
Immunological failure
medicine.disease_cause
01 natural sciences
Biotecnología de la Salud
020901 industrial engineering & automation
Virology
medicine
Humans
0101 mathematics
business.industry
HIV
Models, Theoretical
Early diagnosis
Antiretroviral therapy
3. Good health
Clinical trial
Infectious Diseases
Clinical research
Infection dynamics
business
Otras Biotecnologías de la Salud
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....7bf79af242298778d8ac10a4f700c17e
- Full Text :
- https://doi.org/10.1089/aid.2013.0286