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Mathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Clinical Research Study

Authors :
Vicente Costanza
François Raffi
Djomangan Adama Ouattara
Cécile Brunet
Virginie Ferré
Raphaël Fonteneau
Claude H. Moog
Marie-José Mhawej
Damien Ernst
Xiaohua Xia
Federico L. Biafore
Pablo S. Rivadeneira
Guy-Bart Stan
Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN)
Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN)
Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS)
Imperial College London
Service de maladies infectieuses et tropicales [Nantes]
Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes)
Centre hospitalier universitaire de Nantes (CHU Nantes)
Grupo de Sistemas No Lineales [Santa Fe]
Instituto de Desarrollo Tecnológico para la Industria Química [Sante Fe] (INTEC)
Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional del Litoral [Santa Fe] (UNL)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional del Litoral [Santa Fe] (UNL)
Department of Electrical Engineering and Computer Science (Institut Montefiore)
Université de Liège
Center of Applied Mathematics, School of Science and Technology
National University of San Martin
Department of Electrical, Electronic and Computer Engineering [Pretoria]
University of Pretoria [South Africa]
Source :
AIDS Research and Human Retroviruses, AIDS Research and Human Retroviruses, Mary Ann Liebert, 2014, 30 (9), pp.831-834. ⟨10.1089/AID.2013.0286⟩
Publication Year :
2014
Publisher :
Mary Ann Liebert Inc, 2014.

Abstract

Immunological failure is identified from the estimation of certain parameters of a mathematical model of HIV infection dynamics. This identification is supported by clinical research results from an original clinical trial. Standard clinical data were collected from infected patients starting highly active antiretroviral therapy (HAART) after just 1 month of therapy initiation and were used to carry out the model identification. The early diagnosis is shown to be consistent with patient monitoring after 6 months. Fil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina Fil: Moog, Claude. Centre National de la Recherche Scientifique; Francia Fil: Stan, Guy Bart. Imperial College London; Reino Unido Fil: Costanza, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina Fil: Brunet, Cecile. Universite de Nantes; Francia Fil: Raffi, Francois. Universite de Nantes; Francia Fil: Ferré, Virginie. Universite de Nantes; Francia Fil: Mhawej, Marie José. Centre National de la Recherche Scientifique; Francia Fil: Biafore, Federico Leonardo. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Matematica Aplicada; Argentina Fil: Ouattara, Djomangan. Universite de Nantes; Francia Fil: Ernst, Damien. Universite de Liege; Bélgica Fil: Fonteneau, Raphael. Universite de Liege; Bélgica Fil: Xia, Xiaohua. University of Pretoria; Sudáfrica

Details

ISSN :
19318405 and 08892229
Volume :
30
Database :
OpenAIRE
Journal :
AIDS Research and Human Retroviruses
Accession number :
edsair.doi.dedup.....7bf79af242298778d8ac10a4f700c17e
Full Text :
https://doi.org/10.1089/aid.2013.0286