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Iron kinetics effects of 88 millirads
- Source :
- Cell Biophysics. 13:15-27
- Publication Year :
- 1988
- Publisher :
- Springer Science and Business Media LLC, 1988.
-
Abstract
- Rats were irradiated with one tibia shielded (95% marrow exposure), total body exposed (TBI, 100%), and only one tibia exposed (5%), or they were sham irradiated (SI, 0%). Plasma Fe-59 clearance time (T 1/2) and Fe-59 content ratio in the right and left tibia (RT/LT) were assayed to determine the erythroid activity of the overall marrow of the animals and the relative marrow activity in the exposed and shielded tibias, respectively. When a major fraction of the overall marrow was shielded or irradiated, the overall erythroid activity levels were identical to those of the SI and TBI animals, respectively. Interestingly, enhanced normoblastosis was observed in the marrow of the exposed tibia of individual animals exhibiting normal erythroid activity in 95% of the marrow. Conversely, localized marrow with normal erythroid activity was found in a shielded tibia of individual rats, demonstrating an enhanced erythroid activity in a major fraction of the total body. It was concluded that 88 mrad can alter marrow functions in a small isolated skeletal region as effectively as in the whole body, and tandem assays of the Fe-59T 1/2 and Fe-59 RT/LT can facilitate ultra-low-dose X-ray studies involved with partial body exposures.
- Subjects :
- medicine.medical_specialty
Iron kinetics
Iron
Biophysics
Bone Marrow
Internal medicine
medicine
Animals
Erythropoiesis
Irradiation
Tibia
Bloodletting
Iron Radioisotopes
business.industry
Chemistry
Left tibia
Anemia
Rats, Inbred Strains
Total body
Cell Biology
Rats
Clearance time
Kinetics
Normoblastosis
Endocrinology
Female
Nuclear medicine
business
Whole body
Whole-Body Irradiation
Half-Life
Subjects
Details
- ISSN :
- 01634992
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cell Biophysics
- Accession number :
- edsair.doi.dedup.....7c1dcb8adcc88eec7c776bf7db0f259b