Back to Search
Start Over
The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 76:1485-1490
- Publication Year :
- 2005
- Publisher :
- BMJ, 2005.
-
Abstract
- Background: Mild cognitive impairment (MCI) has been considered a transitional state between normal aging and dementia, characterised by memory impairment but normal general cognitive functioning. Recently other cognitive deficits have been reported. This has led to a modification of MCI criteria. Objective: To examine which neuropsychological tests most clearly distinguish MCI subjects from normal controls. Methods: 112 consecutive MCI subjects and 35 controls were included in the study. The diagnosis of MCI was based on an objective history of cognitive decline and a neuropsychiatric examination, comprising instruments STEP, I-Flex, MMSE, and CDR. Participants were examined with 21 neuropsychological tests in the cognitive domains speed/attention, memory and learning, visuospatial function, language, and executive function. Results: Controls were significantly older. No differences were found in education or general intellectual capacity. Controls performed significantly better than MCI on tests within all five cognitive domains. The clearest differences were seen on language tests, followed by executive function, and learning and memory. Only two subjects (1.8%) were purely amnestic; 17% showed no impairment compared with controls, with a cut off of 1.5 SD below age mean. These subjects were better educated and performed significantly better on measures of general cognitive capacity. Conclusions: The results illustrate the heterogeneity of MCI, with a significant degree of impairment in all five cognitive domains. When examined with a comprehensive neuropsychological battery, very few subjects had an isolated memory impairment.
- Subjects :
- Male
Paper
medicine.medical_specialty
Population
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Severity of Illness Index
Perceptual Disorders
mental disorders
Reaction Time
medicine
Humans
Learning
Memory impairment
Dementia
Cognitive skill
Cognitive decline
Vascular dementia
education
Psychiatry
Aged
Demography
Language Disorders
Memory Disorders
education.field_of_study
Neuropsychology
Cognition
Middle Aged
medicine.disease
nervous system diseases
Psychiatry and Mental health
Space Perception
Mental Recall
Visual Perception
Female
Surgery
Neurology (clinical)
Cognition Disorders
Psychology
human activities
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....7c2c6041443658095a9ee6f1d224cfe9