Back to Search Start Over

3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic dopamine release in the substantia nigra

Authors :
Erik Pileblad
Anders Elverfors
Filip Bergquist
Jan Jonason
Hans Nissbrandt
Sören Lagerkvist
Source :
Journal of neurochemistry. 69(4)
Publication Year :
1997

Abstract

This study was undertaken, using microdialysis, to compare the extracellular concentration of 3-methoxytyramine and dopamine in dialysate from the striatum and substantia nigra, after pargyline (75 mg/kg), after pargyline plus amphetamine (3 mg/kg), and after pargyline plus reserpine (5 mg/kg) administration. Treatment with pargyline alone increased the extracellular dopamine concentration by 70% in the striatum and by 140% in the substantia nigra and induced in both regions a time-dependent accumulation of 3-methoxytyramine. The addition of d-amphetamine to pargyline increased the extracellular dopamine concentration, compared with pargyline-treated controls, to the same extent in both the substantia nigra (maximally by 360%) and the striatum (maximally by 400%), but the concomitant increase of 3-methoxytyramine accumulation in the dialysate was relatively smaller in the substantia nigra compared with the striatum. Reserpine treatment decreased the extracellular dopamine concentration in both regions below the detection level (

Details

ISSN :
00223042
Volume :
69
Issue :
4
Database :
OpenAIRE
Journal :
Journal of neurochemistry
Accession number :
edsair.doi.dedup.....7c2e2a66886a39fc3bbd7b6eb3c6e5fd