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3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic dopamine release in the substantia nigra
- Source :
- Journal of neurochemistry. 69(4)
- Publication Year :
- 1997
-
Abstract
- This study was undertaken, using microdialysis, to compare the extracellular concentration of 3-methoxytyramine and dopamine in dialysate from the striatum and substantia nigra, after pargyline (75 mg/kg), after pargyline plus amphetamine (3 mg/kg), and after pargyline plus reserpine (5 mg/kg) administration. Treatment with pargyline alone increased the extracellular dopamine concentration by 70% in the striatum and by 140% in the substantia nigra and induced in both regions a time-dependent accumulation of 3-methoxytyramine. The addition of d-amphetamine to pargyline increased the extracellular dopamine concentration, compared with pargyline-treated controls, to the same extent in both the substantia nigra (maximally by 360%) and the striatum (maximally by 400%), but the concomitant increase of 3-methoxytyramine accumulation in the dialysate was relatively smaller in the substantia nigra compared with the striatum. Reserpine treatment decreased the extracellular dopamine concentration in both regions below the detection level (
- Subjects :
- Male
medicine.medical_specialty
Dextroamphetamine
Monoamine Oxidase Inhibitors
Reserpine
Dopamine
Dopamine Agents
Substantia nigra
Striatum
Biochemistry
Rats, Sprague-Dawley
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Internal medicine
medicine
3-Methoxytyramine
Animals
Chemistry
Osmolar Concentration
Homovanillic Acid
Dendrites
Pargyline
Rats
Substantia Nigra
Drug Combinations
Endocrinology
nervous system
Dopamine receptor
Catecholamine
3,4-Dihydroxyphenylacetic Acid
Extracellular Space
medicine.drug
Subjects
Details
- ISSN :
- 00223042
- Volume :
- 69
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistry
- Accession number :
- edsair.doi.dedup.....7c2e2a66886a39fc3bbd7b6eb3c6e5fd