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Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System
- Source :
- Digital.CSIC: Repositorio Institucional del CSIC, Consejo Superior de Investigaciones Científicas (CSIC), Journal of Personalized Medicine, Journal of Personalized Medicine, Vol 11, Iss 475, p 475 (2021), Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2021
- Publisher :
- Molecular Diversity Preservation International, 2021.
-
Abstract
- The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems.<br />The authors included in this review have received funding for two COVID-19 projects (COVID GWAs, Premed COVID-19) from the Consejería de Salud y Familias of the Andalusian Government. DMM‘s contract is supported by the Andalussian government (Proyectos Estratégicos Fondos Feder PE-0451-2018).
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Epidemiology
precision medicine
Medicine (miscellaneous)
Disease
Review
Viral genome
03 medical and health sciences
0302 clinical medicine
Health care
Pandemic
medicine
030212 general & internal medicine
Intensive care medicine
business.industry
SARS-CoV-2
SARS CoV2
Public health
viral genome
Precision medicine
COVID-19
personalized medicine
Personalized medicine
Clinical trial
Host genetics
030104 developmental biology
host genetics
Medicine
epidemiology
business
Covid-19
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC: Repositorio Institucional del CSIC, Consejo Superior de Investigaciones Científicas (CSIC), Journal of Personalized Medicine, Journal of Personalized Medicine, Vol 11, Iss 475, p 475 (2021), Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....7c40d363a199f55d6b0dbc8dde5b7b41
- Full Text :
- https://doi.org/10.13039/501100011011