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Myeloid-derived Suppressor Cells in Cancer Patients
- Source :
- Journal of Immunotherapy. 35:107-115
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensively investigated in preclinical models, especially in the context of cancer. One of the major obstacles in their accurate identification has been the definition of an unambiguous phenotype, shared between mice and humans, and clearly correlating with their suppressive function. In this paper, we review the literature concerning the phenotype in mouse and in humans, showing that at least 2 subsets of MDSCs are present under different situations. We also address the role of MDSCs in tumor progression, evaluate the prognostic significance of MDSC in cancer patients, and their possible role as marker of clinical outcome and response to therapy. Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies.
- Subjects :
- Cancer Research
Immunology
Context (language use)
myeloid cells, myeloid-derived suppressor cells, suppression
Biology
law.invention
Mice
Immune system
law
Neoplasms
medicine
Animals
Humans
Immunology and Allergy
Pharmacology
Cancer
suppression
myeloid-derived suppressor cells
medicine.disease
Phenotype
myeloid cells
Tumor progression
Myeloid-derived Suppressor Cell
Suppressor
Tumor Escape
Function (biology)
Subjects
Details
- ISSN :
- 15249557
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Journal of Immunotherapy
- Accession number :
- edsair.doi.dedup.....7c471e1181b2d5db90fa173d5a287cd0