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MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy Human Individuals
- Source :
- Genomics, proteomics & bioinformatics, vol 18, iss 2, Genomics, Proteomics & Bioinformatics, Genomics, Proteomics & Bioinformatics, Vol 18, Iss 2, Pp 140-149 (2020)
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- Mosaic variants resulting from postzygotic mutations are prevalent in the human genome and play important roles in human diseases. However, except for cancer-related variants, there is no collection of postzygotic mosaic variants in noncancer disease-related and healthy individuals. Here, we present MosaicBase, a comprehensive database that includes 6698 mosaic variants related to 266 noncancer diseases and 27,991 mosaic variants identified in 422 healthy individuals. Genomic and phenotypic information of each variant was manually extracted and curated from 383 publications. MosaicBase supports the query of variants with Online Mendelian Inheritance in Man (OMIM) entries, genomic coordinates, gene symbols, or Entrez IDs. We also provide an integrated genome browser for users to easily access mosaic variants and their related annotations for any genomic region. By analyzing the variants collected in MosaicBase, we find that mosaic variants that directly contribute to disease phenotype show features distinct from those of variants in individuals with mild or no phenotypes, in terms of their genomic distribution, mutation signatures, and fraction of mutant cells. MosaicBase will not only assist clinicians in genetic counseling and diagnosis but also provide a useful resource to understand the genomic baseline of postzygotic mutations in the general human population. MosaicBase is publicly available at http://mosaicbase.com/ or http://49.4.21.8:8000.
- Subjects :
- Postzygotic
Zygote
Knowledge Bases
medicine.disease_cause
Biochemistry
Mathematical Sciences
User-Computer Interface
0302 clinical medicine
Noncancer
Integrated Genome Browser
Databases, Genetic
OMIM : Online Mendelian Inheritance in Man
2.1 Biological and endogenous factors
Disease
Aetiology
lcsh:QH301-705.5
Genetics
0303 health sciences
education.field_of_study
Mutation
Genome
Mosaicism
Biological Sciences
Phenotype
Computational Mathematics
Health
Human
Biotechnology
Bioinformatics
Genetic counseling
MosaicBase
Population
Biology
Database
03 medical and health sciences
Databases
Rare Diseases
Genetic
Information and Computing Sciences
medicine
Humans
education
Molecular Biology
Gene
030304 developmental biology
Genome, Human
Human Genome
lcsh:Biology (General)
Human genome
030217 neurology & neurosurgery
Software
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Genomics, proteomics & bioinformatics, vol 18, iss 2, Genomics, Proteomics & Bioinformatics, Genomics, Proteomics & Bioinformatics, Vol 18, Iss 2, Pp 140-149 (2020)
- Accession number :
- edsair.doi.dedup.....7c6f2d60bedb6af15e7a669cc6ac9b0f