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Endothelial cell fitness dictates the source of regenerating liver vasculature

Authors :
Jianing Dai
Xiaoting Liu
Nicolas Gengenbacher
Mahak Singhal
Kai Jiang
Weiping Li
Lijian Hui
Hellmut G. Augustin
Susanne Bartels
Eva Besemfelder
Ashik Ahmed Abdul Pari
Hao He
Junhao Hu
Donato Inverso
Source :
The Journal of Experimental Medicine, Journal of Experimental Medicine
Publication Year :
2018

Abstract

In this issue of JEM, Singhal et al. explore the cellular mechanisms involved in endothelial cell regeneration in the liver. Using a combination of myeloablative and nonmyeloablative approaches, the authors found that repair of the endothelium is mediated by endothelial cells themselves, but when injured, endothelial cells enlist myeloid counterparts that aid in vascular repair.<br />In this issue of JEM, Singhal et al. (https://doi.org/10.1084/jem.20180008) explore the cellular mechanisms involved in endothelial cell regeneration in the liver. Using a combination of myeloablative and nonmyeloablative approaches, the authors found that repair of the endothelium is mediated by endothelial cells themselves, but when injured, endothelial cells enlist myeloid counterparts that aid in vascular repair.

Details

ISSN :
15409538
Volume :
215
Issue :
10
Database :
OpenAIRE
Journal :
The Journal of experimental medicine
Accession number :
edsair.doi.dedup.....7c84a2c72da6f45e0e9d4fcb4d8c3e2c