Back to Search
Start Over
Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes
- Source :
- Molecules, Vol 24, Iss 1, p 187 (2019), Molecules, Volume 24, Issue 1
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Four previously undescribed compounds, including three rarely occurring seco-dammarane triterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of the leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures were determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical methods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both 3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased glucose uptake through activating AMP-activated protein kinase (AMPK)-p38 pathway. Collectively, triterpenoids from C. paliurus could be developed as insulin sensitizers, which might have therapeutic potential for insulin resistance and hyperglycemia.
- Subjects :
- medicine.medical_treatment
Glucose uptake
Phytochemicals
Pharmaceutical Science
01 natural sciences
Analytical Chemistry
Mice
AMP-Activated Protein Kinase Kinases
Drug Discovery
Insulin
Glycosides
chemistry.chemical_classification
0303 health sciences
biology
Molecular Structure
Paliurus
Biochemistry
Chemistry (miscellaneous)
Molecular Medicine
Cyclocarya
Cyclocarya paliurus (Juglandaceae)
Signal Transduction
Cell Survival
adipocytes
Article
Juglandaceae
lcsh:QD241-441
03 medical and health sciences
Structure-Activity Relationship
Insulin resistance
lcsh:Organic chemistry
3T3-L1 Cells
medicine
Animals
Physical and Theoretical Chemistry
030304 developmental biology
010405 organic chemistry
Plant Extracts
Terpenes
Organic Chemistry
AMPK
Glycoside
3T3-L1
Biological Transport
medicine.disease
biology.organism_classification
0104 chemical sciences
glucose uptake
Plant Leaves
Glucose
chemistry
seco-dammarane triterpenoids
Protein Kinases
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....7c8f2ed200fd9e1a34269badab162d2b