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Triterpenoids from Cyclocarya paliurus that Enhance Glucose Uptake in 3T3-L1 Adipocytes

Authors :
Shengnan Shen
Jia-Min Wang
Jian-Xia Mo
Chang-Xin Zhou
Yongjiang Wu
Li-She Gan
Zhu-Jun Fang
Ligen Lin
Source :
Molecules, Vol 24, Iss 1, p 187 (2019), Molecules, Volume 24, Issue 1
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Four previously undescribed compounds, including three rarely occurring seco-dammarane triterpenoid glycosides and a pentacyclic triterpenic acid, were isolated from a 70% ethanol extract of the leaves of Cyclocarya paliurus (Juglandaceae), along with eleven known triterpenoids. Their structures were determined by spectroscopic techniques, including 2D NMR and HRESIMS, as well as chemical methods. Among them, several triterpenoids enhanced insulin stimulated glucose uptake in both 3T3-L1 adipocytes and C2C12 myotubes. Furthermore, compound 1 dose-dependently increased glucose uptake through activating AMP-activated protein kinase (AMPK)-p38 pathway. Collectively, triterpenoids from C. paliurus could be developed as insulin sensitizers, which might have therapeutic potential for insulin resistance and hyperglycemia.

Details

Language :
English
ISSN :
14203049
Volume :
24
Issue :
1
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....7c8f2ed200fd9e1a34269badab162d2b