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Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA
- Source :
- PeerJ, PeerJ, Vol 7, p e6555 (2019)
- Publication Year :
- 2019
- Publisher :
- PeerJ Inc., 2019.
-
Abstract
- BackgroundAdrenocortical carcinoma (ACC) is a rare and aggressive malignant cancer in the adrenal cortex with poor prognosis. Though previous research has attempted to elucidate the progression of ACC, its molecular mechanism remains poorly understood.MethodsGene transcripts per million (TPM) data were downloaded from the UCSC Xena database, which included ACC (The Cancer Genome Atlas,n= 77) and normal samples (Genotype Tissue Expression,n= 128). We used weighted gene co-expression network analysis to identify gene connections. Overall survival (OS) was determined using the univariate Cox model. A protein–protein interaction (PPI) network was constructed by the search tool for the retrieval of interacting genes.ResultsTo determine the critical genes involved in ACC progression, we obtained 2,953 significantly differentially expressed genes and nine modules. Among them, the blue module demonstrated significant correlation with the “Stage” of ACC. Enrichment analysis revealed that genes in the blue module were mainly enriched in cell division, cell cycle, and DNA replication. Combined with the PPI and co-expression networks, we identified four hub genes (i.e.,TOP2A,TTK,CHEK1, andCENPA) that were highly expressed in ACC and negatively correlated with OS. Thus, these identified genes may play important roles in the progression of ACC and serve as potential biomarkers for future diagnosis.
- Subjects :
- Bioinformatics
lcsh:Medicine
Computational biology
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
medicine
Genetics
Adrenocortical carcinoma
CHEK1
ACC
Gene
030304 developmental biology
0303 health sciences
CENPA
Progression
Adrenal cortex
Proportional hazards model
WGCNA
General Neuroscience
lcsh:R
DNA replication
General Medicine
Cell cycle
medicine.disease
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
General Agricultural and Biological Sciences
Hub genes
Subjects
Details
- Language :
- English
- ISSN :
- 21678359
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PeerJ
- Accession number :
- edsair.doi.dedup.....7c96571dc9b68e189515a50af6e51d56