Back to Search Start Over

Static cut‐points of hypertension and increased arterial stiffness in children and adolescents: The International Childhood Vascular Function Evaluation Consortium

Authors :
Polyana Romano Oliosa
Yi Zhang
Da yan Niu
Costan G. Magnussen
Bo Xi
Kai Mu
Rafael de Oliveira Alvim
Hae Soon Kim
Wei Li Yan
Yuan Jiang
Ana Isabel Mora-Urda
Pouya Saeedi
Divanei Zaniqueli
Pilar Montero López
Young Mi Hong
Eliane Rodrigues de Faria
Min Zhao
José Geraldo Mill
Paula M L Skidmore
Anuradha Khadilkar
Lee Stoner
Source :
J Clin Hypertens (Greenwich)
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

Pediatric elevated blood pressure (BP) and hypertension are usually defined using traditional BP tables at the 90th and 95th percentiles, respectively, based on sex, age, and height, which are cumbersome to use in clinical practice. The authors aimed to assess the performance of the static cut‐points (120/80 mm Hg and 130/80 mm Hg for defining elevated BP and hypertension for adolescents, respectively; and 110/70 mm Hg and 120/80 mm Hg for children, respectively) in predicting increased arterial stiffness. Using data from five population‐based cross‐sectional studies conducted in Brazil, China, Korea, and New Zealand, a total of 2546 children and adolescents aged 6‐17 years were included. Increased arterial stiffness was defined as pulse wave velocity ≥sex‐specific, age‐specific, and study population‐specific 90th percentile. Compared to youth with normal BP, those with hypertension defined using the 2017 American Academy of Pediatrics guideline (hereafter referred to as “percentile‐based cut‐points”) and the static cut‐points were at similar risk of increased arterial stiffness, with odds ratios and 95% confidence intervals of 2.35 (1.74‐3.17) and 3.07 (2.20‐4.28), respectively. Area under the receiver operating characteristic curve and net reclassification improvement methods confirmed the similar performance of static cut‐points and percentile‐based cut‐points (P for difference > .05). In conclusion, the static cut‐points performed similarly well when compared with the percentile‐based cut‐points in predicting childhood increased arterial stiffness. Use of static cut‐points to define hypertension in childhood might simplify identification of children with abnormal BP in clinical practice.

Details

ISSN :
17517176 and 15246175
Volume :
21
Database :
OpenAIRE
Journal :
The Journal of Clinical Hypertension
Accession number :
edsair.doi.dedup.....7caf728ebf058bb1245647a640820501
Full Text :
https://doi.org/10.1111/jch.13642