miR-204 suppresses the development and progression of human glioblastoma by targeting ATF2

// Shiwei Song 1 , Abul Fajol 2 , Xiankun Tu 1 , Baogang Ren 1 , Songsheng Shi 1 1 Department of Neurosurgery, Fujian Medical University Affiliated Union Hospital, Fujian Neurosurgical Institute, Fuzhou, 350001, China 2 Department of Clinical Sciences, CRC, Lund University, Malmo, 20502, Sweden Correspondence to: Shiwei Song, email: songshiweifmu@163.com Keywords: miR-204, GBM, suppressor Received: June 21, 2016 Accepted: August 16, 2016 Published: August 31, 2016 ABSTRACT In human cancers, miRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed, and their alterations contribute to multiple cancer development and progression. Till now, little has been known about the role of miR-204 in human glioblastoma (GBM). In the present study, we used in-vitro assays to investigate the mechanisms of miR-204 in GBM cell lines and 60 cases of GBM tissues. Here, we found that miR-204 expression is downregulated in both GBM cell lines A172, U87 and U251 cells and GBM tissues as compared with NHA cells and normal tissues (all p