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Different reference ranges affect the prevalence of osteoporosis and osteopenia in an urban adult Malaysian population
- Source :
- Osteoporosis and Sarcopenia, Osteoporosis and Sarcopenia, Vol 6, Iss 4, Pp 168-172 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objectives To determine the prevalence of osteopenia (OPe) and osteoporosis (OP) in an urban adult population in Malaysia, and to compare the change in the prevalence when using a Caucasian compared to an Asian reference range. Methods A cross-sectional random sample of the population aged between 45 and 90 years from the state of Selangor, Malaysia, was invited to attend a bone health check-up. Participants with diseases known to affect bone metabolism or who were on treatment for OP were excluded. Bone mineral density was measured using dual energy X-ray absorptiometry. Based on the World Health Organization definitions, the prevalence of OPe and OP was calculated using the Asian and Caucasian T-scores. Results A total of 342 subjects (222 females, 120 males), with a mean age of 59.68 (standard deviation: 8.89) years, who fulfilled the study criteria were assessed. Based on the Asian reference range, there were 140 (40.9%) subjects with OPe and 48 (14.0%) with OP. On applying the Caucasian reference range, there were 152 (44.4%) subjects with OPe and 79 (23.1%) with OP, with significant increases in males, females, and Chinese ethnic groups. Overall, 75 (21.9%) of subjects had a change in their diagnostic status. T-scores were consistently lower when the Caucasian reference range was used. Conclusions In a healthy urban Malaysian population, the prevalence of OP is 14.0% and OPe is 40.9%. Application of a Caucasian reference range significantly increased the number of subjects with OP and may potentially lead to over-treatment.
- Subjects :
- 0301 basic medicine
lcsh:Diseases of the musculoskeletal system
Population
Osteoporosis
Ethnic group
Reference ranges
030209 endocrinology & metabolism
Reference range
Affect (psychology)
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Medicine
education
Bone mineral
education.field_of_study
Osteopenia
business.industry
Malaysia
medicine.disease
Original Article
030101 anatomy & morphology
lcsh:RC925-935
business
Demography
Subjects
Details
- ISSN :
- 24055255
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Osteoporosis and Sarcopenia
- Accession number :
- edsair.doi.dedup.....7cc5dad3f7681ecd47f4204001d42af5