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Rheumatoid factor and tumor-host interaction

Authors :
Roger D. Rossen
Verna M. Lewis
Jeremiah J. Twomey
A H Laughter
C C Douglass
Source :
Proceedings of the National Academy of Sciences. 73:2106-2108
Publication Year :
1976
Publisher :
Proceedings of the National Academy of Sciences, 1976.

Abstract

In this survey for rheumatoid factor (RF) seropositivity on patients with neoplasms, an 85% rate of positive screening tests was recorded under certain circumstances. This high rate of RF seropositivity occurred after irradiation and/or chemotherapy of breast and lung cancers. Treated patients with breast cancers who had no evidence of residual tumor had an 89% rate of positive RF tests. Conversely, the incidence of RF seropositivity was low among untreated patients with similar tumors and treated patients with glioblastomas or multiple myeloma. The administration of cytotoxic drugs (e.g., azathiprene) was not itself associated with RF production even in renal allograft recipients. The data indicate that RF production occurs frequently after therapy of certain tumors and suggest that in these circumstances RF may be an expression of tumor-host interaction.

Details

ISSN :
10916490 and 00278424
Volume :
73
Database :
OpenAIRE
Journal :
Proceedings of the National Academy of Sciences
Accession number :
edsair.doi.dedup.....7cd26c192e4dff24023c3a8857b6a458
Full Text :
https://doi.org/10.1073/pnas.73.6.2106