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Reduced T cell immunity in unmedicated, comorbidity-free obsessive-compulsive disorder: An immunophenotyping study
- Source :
- Journal of Psychiatric Research. 137:521-524
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Immune system aberrations have been postulated to play a role in the pathophysiology of Obsessive-compulsive disorder (OCD). This study was aimed to examine the profile of immune cell subsets in peripheral blood of un-medicated OCD patients. Method Thirteen drug-naive/free OCD patients and twenty-six age & sex matched healthy controls were recruited. Immunophenotyping was carried out by staining the whole blood specimens with fluorescent monoclonal antibodies against the cell surface markers such as CD45, CD3, CD16, CD56, CD8, CD4, CD28, CD25 and CD127, followed by data acquisition on BD FACSVerseā¢ flow cytometer. The proportions of CD4 and CD8 T cells; T regulatory (Tregs), Natural Killer (NK) cells and NK-T cells were compared between patients with OCD and healthy control subjects. Results Significantly reduced percentage of T regulatory (Treg) cells was observed in individuals with OCD compared to healthy control subjects [1.0 ± 0.7 vs. 1.9 ± 1.4; p = 0.03, r = 0.33]. Conclusion Treg cells play a crucial role in regulating the immune response, especially by suppressing the functional activities of T cells. In this study, decreased population of Treg cells essentially indicates a dysregulated T cell and/or T cell mediated immune activation in drug-naive OCD patients. This preliminary observation might form the basis of further studies examining the immuno-inflammatory/autoimmune origin of OCD.
- Subjects :
- Obsessive-Compulsive Disorder
T cell
chemical and pharmacologic phenomena
T-Lymphocytes, Regulatory
Immunophenotyping
03 medical and health sciences
0302 clinical medicine
Immune system
Humans
Medicine
Cytotoxic T cell
IL-2 receptor
Biological Psychiatry
Cluster of differentiation
business.industry
CD28
Flow Cytometry
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Pharmaceutical Preparations
Immunology
business
030217 neurology & neurosurgery
CD8
Subjects
Details
- ISSN :
- 00223956
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatric Research
- Accession number :
- edsair.doi.dedup.....7cf91b83d22feea2351f0634141507b7