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Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans

Authors :
Thomas Sandström
Nikolai Stenfors
Ian Mudway
Sean T Duggan
Christoffer Boman
Ragnberth Helleday
Susan J. Wilson
Anthony J. Frew
Annelie F. Behndig
Frank J. Kelly
Flemming R. Cassee
Joanna L Brown
Anders Blomberg
Source :
The European respiratory journal. 27(2)
Publication Year :
2006

Abstract

Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. In the present study, the authors examined whether similar responses occurred in vivo, specifically whether antioxidants were upregulated following a low-dose DE challenge and investigated how these responses related to the development of airway inflammation at different levels of the respiratory tract where particle dose varies markedly. A total of 15 volunteers were exposed to DE (100 microg x m(-3) airborne particulate matter with a diameter of

Details

ISSN :
09031936
Volume :
27
Issue :
2
Database :
OpenAIRE
Journal :
The European respiratory journal
Accession number :
edsair.doi.dedup.....7d276ec1e4ff2f05fae10774cf19b70d