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Inpatient hospital burden of hepatitis C-diagnosed patients with decompensated cirrhosis
- Source :
- Liver International. 38:1402-1410
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background & aims To describe the burden on inpatient hospital resources over time from patients diagnosed with hepatitis C virus (HCV) infection and who have reached the decompensated stage of cirrhosis (DC), as existing estimates of hospital stay in these patients are limited. Methods A retrospective longitudinal dataset was formed via record-linkage between the national HCV diagnosis database and inpatient/daycase hospitalisation and death registers in Scotland. The study population consisted of HCV-diagnosed patients with a first DC admission in 1996-2013, with follow-up available until 31 May 2014. We investigated and quantified the mean cumulative length of hospital stay, distributions over discharge diagnosis categories, and trends in admission rates. Results Among our study population (n = 1543), we identified 10 179 admissions with any diagnosis post-first DC admission. Between 1996 and 2013 there was a 16-fold rise in annual total admissions (from 112 to 1791) and an 11-fold rise in hospital stay (719-8045). When restricting minimum possible follow-up to 2 years, DC patients (n = 1312) had an overall admission rate of 7.3 per person-year, and spent on average 43 days (26 days during first 6 months) in hospital; for all liver-related, liver-related other than HCC/DC, and non-liver related only admissions, this was 39, 14, and 5 days respectively. Conclusions HCV-infected DC patients impose a considerable inpatient hospital burden, mostly from DC- and other liver-related admissions, but also from admissions associated with non-liver comorbidities. Estimates will be useful for monitoring the impact of prevention and treatment, and for computing the cost-effectiveness of new therapies.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Databases, Factual
Cost-Benefit Analysis
Hepatitis C virus
Hepacivirus
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Cost of Illness
medicine
Humans
Longitudinal Studies
Stage (cooking)
Aged
Proportional Hazards Models
Retrospective Studies
Inpatients
Hepatology
business.industry
Admission rate
Hepatitis C
Hepatitis C, Chronic
Length of Stay
Middle Aged
medicine.disease
Decompensated cirrhosis
Scotland
030220 oncology & carcinogenesis
Emergency medicine
Population study
Female
030211 gastroenterology & hepatology
business
Hospital stay
Subjects
Details
- ISSN :
- 14783223
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Liver International
- Accession number :
- edsair.doi.dedup.....7d2b0eed3c43adc88b0d97f50b6533f3