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Addressing Cellular Heterogeneity in Cancer through Precision Proteomics
- Source :
- Journal of proteome research.
- Publication Year :
- 2020
-
Abstract
- Cells exhibit a broad spectrum of functions driven by differences in molecular phenotype. Understanding the heterogeneity between and within cell types has led to advances in our ability to diagnose and manipulate biological systems. Heterogeneity within and between tumors still poses a challenge to the development and efficacy of therapeutics. In this Perspective we review the toolkit of protein-level experimental approaches for investigating cellular heterogeneity. We describe how innovative approaches and technical developments have supported the advent of bottom-up single-cell proteomic analysis and present opportunities and challenges within cancer research. Finally, we introduce the concept of "precision proteomics" and discuss how the advantages and limitations of various experimental approaches render them suitable for different biological systems and questions.
- Subjects :
- 0301 basic medicine
030102 biochemistry & molecular biology
Computer science
Molecular phenotype
Cancer
General Chemistry
Computational biology
Proteomics
medicine.disease
Biochemistry
03 medical and health sciences
Broad spectrum
030104 developmental biology
Cellular heterogeneity
Intratumor heterogeneity
medicine
Subjects
Details
- ISSN :
- 15353907
- Database :
- OpenAIRE
- Journal :
- Journal of proteome research
- Accession number :
- edsair.doi.dedup.....7d2f16c67fcd3df0907a508bd2dda328