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A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
- Source :
- Case Reports in Dermatology, Case Reports in Dermatology, Vol 11, Iss 3, Pp 334-337 (2019)
- Publication Year :
- 2019
- Publisher :
- S. Karger AG, 2019.
-
Abstract
- We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema after the initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine but positive for SASP. In this case, DIHS developed with SASP in association with HHV-6 and CMV reactivation. The immunocompromised state induced by herpes virus reactivation and mizoribine might have caused the relapse of skin erythema.
- Subjects :
- Skin erythema
viruses
Human herpesvirus 6
Hypersensitivity syndrome
Single Case
Congenital cytomegalovirus infection
Cytomegalovirus
Dermatology
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Drug-induced hypersensitivity syndrome
lcsh:Dermatology
medicine
Salazosulfapyridine
Relapse
Serum dna
Mizoribine
biology
integumentary system
business.industry
fungi
virus diseases
lcsh:RL1-803
medicine.disease
biology.organism_classification
Titer
030220 oncology & carcinogenesis
Rheumatoid arthritis
Immunology
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16626567
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Case Reports in Dermatology
- Accession number :
- edsair.doi.dedup.....7d601ac9133deaf86d76b6f61376ba6a