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Nutrition Risk Index Score at Diagnosis Can Effectively Predict Poor Prognosis in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
- Source :
- Journal of Renal Nutrition. 32:423-431
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Objectives This study investigated whether the nutritional risk index (NRI) score at diagnosis might be useful for anticipating poor prognosis, in particular, all-cause mortality and end-stage renal disease (ESRD) in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods The medical records of 242 immunosuppressive drug-naive patients with AAV were retrospectively reviewed. Data at diagnosis and poor prognosis and medications during follow-up were assessed. The NRI score was calculated by 1.519 × serum albumin (g/L) + 41.7 × present (kg)/ideal body weight (kg). Results The median age at diagnosis of patients with AAV (131 microscopic polyangiitis, 62 granulomatosis with polyangiitis, and 49 eosinophilic granulomatosis with polyangiitis) was 60 years (85 male). During follow-up, twenty-nine patients (12.0%) died after a period of 35.9 months, and 42 patients (17.4%) had ESRD for a period of 30.0 months. Using the receiver operator characteristic curve, the cutoffs of the NRI scores for all-cause mortality and ESRD were calculated as NRI ≤ 101.95 (sensitivity, 46.5%; specificity, 89.7%) and NRI ≤ 99.85 (sensitivity, 57.0%; specificity, 83.3%). In the multivariable Cox hazard model analyses, age (hazard ratio [HR], 1.035), five-factor score (HR, 1.623), and the NRI score ≤ 101.95 (HR, 4.262) were independent predictors of all-cause mortality, whereas, five-factor score (HR, 1.516), hypertension (HR, 1.906), and the NRI score ≤ 99.85 (HR, 3.623) were independent predictors of ESRD occurrence during follow-up in patients with AAV. Conclusions The NRI score at diagnosis may be a useful index to anticipate all-cause mortality and ESRD occurrence during follow-up in patients with AAV.
- Subjects :
- Male
medicine.medical_specialty
Medicine (miscellaneous)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Disease
Churg-Strauss Syndrome
Gastroenterology
Antibodies, Antineutrophil Cytoplasmic
Internal medicine
medicine
Humans
Retrospective Studies
Anti-neutrophil cytoplasmic antibody
Nutrition and Dietetics
Receiver operating characteristic
Proportional hazards model
business.industry
Hazard ratio
Granulomatosis with Polyangiitis
Prognosis
medicine.disease
Nephrology
Kidney Failure, Chronic
Granulomatosis with polyangiitis
Microscopic polyangiitis
business
Vasculitis
Subjects
Details
- ISSN :
- 10512276
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Renal Nutrition
- Accession number :
- edsair.doi.dedup.....7d6b7ba2c8598e34f5acaec986a5f28f