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The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
- Source :
- Journal of Clinical Epidemiology, Rooshenas, L, Scott, L J, Blazeby, J M, Rogers, C A, Tilling, K M, Husbands, S, Conefrey, C, Mills, N, Metcalfe, C, Carr, A J, Beard, D, Davis, T, Paramasivan, S & Jepson, M & Avery, K & Elliott, D & Wilson, C A & Donovan, J L & Macpherson, I E 2019, ' The QuinteT Recruitment Intervention supported five randomized trials to recruit to target : a mixed-methods evaluation ', Journal of Clinical Epidemiology, vol. 106, pp. 108-120 . https://doi.org/10.1016/j.jclinepi.2018.10.004, L, R, Lj, S, Jm, B, Ca, R, Km, T, S, H, C, C, N, M, Rc, S, C, M, Aj, C, Dj, B, T, D, S, P, M, J, K, A, D, E, C, W, Jl, D, Rogers, C A, Andrews, R, Blazeby, J M, Byrne, J, Donovan, J L, Kelly, J, Mazza, G, Mahon, D, Noble, H, Reeves, B C, Thompson, J L, Wordsworth, S, Welbourn, R, Beard, D, Carr, A, Cook, J, Cooper, C, Dean, B, Donovan, J L, Gray, A, Gwilym, S, Judge, A, Merritt, N, Moser, J, Rees, J, Rombach, I, Savulescu, J, Tracey, I, Wartolowska, K, Tan, W, Mills, N, Karantana, A, Sprange, K, Duley, L, Elliott, D, Blazeby, J M, Hollingworth, W, Montgomery, A A, Davis, T, Stein, R, Bartlett, J, Cameron, D, Campbell, A, Canney, P, Donovan, J L, Dunn, J, Earl, H, Falzon, M, Francis, A, Hall, P, Harmer, V, Higgins, H, Hiller, L, Hughes-davies, L, Hulme, C, Macpherson, I, Makris, A, Marshall, A, Mccabe, C, Morgan, A, Pinder, S, Poole, C, Provenzano, E, Rea, D, Stallard, N, Avery, K N, Barham, C P, Berrisford, R, Blazeby, J M, Donovan, J L, Elliott, J, Falk, S J, Goldin, R, Hanna, G, Hollowood, A A, Krysztopik, R, Metcalfe, C, Noble, S, Sanders, G, Streets, C G, Titcomb, D R & Wheatley, T 2018, ' The Quintet Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation ', Journal of Clinical Epidemiology . https://doi.org/10.1016/j.jclinepi.2018.10.004, https://doi.org/10.1016/j.jclinepi.2018.10.004
- Publication Year :
- 2018
-
Abstract
- Objective To evaluate the impact of the QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties and then implements “QRI actions” to address these as recruitment proceeds. Study Design and Setting A mixed-methods study, comprising (1) before-and-after comparisons of recruitment rates and the numbers of patients approached and (2) qualitative case studies, including documentary analysis and interviews with RCT investigators. Results Five UK-based publicly funded RCTs were included in the evaluation. All recruited to target. Randomized controlled trial 2 and RCT 5 both received up-front prerecruitment training before the intervention was applied. Randomized controlled trial 2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI actions in RCTs 1, 3, 4, and 5. Randomization rates significantly improved after QRI action in RCTs 1, 3, and 4. Quintet Recruitment Intervention actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in the number of patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of and reportedly changed their practices after QRI action. Conclusion There is promising evidence to suggest that the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.
- Subjects :
- medicine.medical_specialty
Randomization
Epidemiology
Training healthcare professionals
BTC (Bristol Trials Centre)
Article
law.invention
03 medical and health sciences
0302 clinical medicine
Clinical Protocols
Randomized controlled trial
law
Qualitative research
Intervention (counseling)
Humans
Medicine
030212 general & internal medicine
Communication issues
Randomized Controlled Trials as Topic
business.industry
Patient Selection
Communication
Clinical Trial
3. Good health
Clinical trial
Centre for Surgical Research
Physical therapy
Recruitment
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 18785921 and 08954356
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Epidemiology
- Accession number :
- edsair.doi.dedup.....7d8b9842e71340b60e1aee3d7c343d1a
- Full Text :
- https://doi.org/10.1016/j.jclinepi.2018.10.004