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The role of tacrolimus in renal transplantation
- Source :
- Expert Opinion on Pharmacotherapy. 9:635-643
- Publication Year :
- 2008
- Publisher :
- Informa Healthcare, 2008.
-
Abstract
- Tacrolimus gained FDA approval for use in liver transplantation in 1994 and, approximately 3 years later, was approved for the prevention of acute rejection in kidney transplantation. Over the last decade tacrolimus has become the calcineurin inhibitor of choice for the prevention of rejection in renal transplantation. The objective of this study was to provide a review and update of the literature on the use of tacrolimus in renal transplantation. Numerous clinical trials have shown tacrolimus to be superior to cyclosporine in the prevention of acute rejection and recent trials have demonstrated superiority of tacrolimus over cyclosporine in terms of allograft survival. Post-transplant diabetes remains more common with tacrolimus than cyclosporine, despite lower doses of both tacrolimus and corticosteroids. A novel once-daily dosage form of tacrolimus has recently been developed and is approved for use in Europe. Tacrolimus remains an important immunosuppressant for the prevention of acute rejection. The prolonged-release formulation may improve compliance and possibly long-term outcomes.
- Subjects :
- Graft Rejection
medicine.medical_specialty
Cost-Benefit Analysis
medicine.medical_treatment
Urology
chemical and pharmacologic phenomena
Liver transplantation
Drug Costs
Tacrolimus
Pharmacotherapy
Diabetes mellitus
medicine
Humans
Drug Interactions
Pharmacology (medical)
Kidney transplantation
Pharmacology
Evidence-Based Medicine
business.industry
General Medicine
Mycophenolic Acid
medicine.disease
Kidney Transplantation
Clinical trial
Transplantation
Calcineurin
Treatment Outcome
surgical procedures, operative
Cyclosporine
Drug Therapy, Combination
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 17447666 and 14656566
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....7dad71ca859c5faaed9f5a19dac9618d
- Full Text :
- https://doi.org/10.1517/14656566.9.4.635