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Recent advances in managing HIV-associated cryptococcal meningitis
- Source :
- F1000Research
- Publication Year :
- 2019
- Publisher :
- F1000 Research Ltd, 2019.
-
Abstract
- The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes. However, diagnostic advances have not been matched by new antifungal drugs and treatment still relies on old off-patent drugs: amphotericin B, flucytosine and fluconazole. Cryptococcal meningitis treatment is divided in three phases: induction, consolidation and maintenance. The induction phase, aimed at drastically reducing cerebrospinal fluid fungal burden, is key for patient survival. The major challenge in cryptococcal meningitis management has been the optimisation of induction phase treatment using the limited number of available medications, and major progress has recently been made. In this review, we summarise data from key trials which form the basis of current treatment recommendations for HIV-associated cryptococcal meningitis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Antifungal Agents
Antifungal drugs
030106 microbiology
Human immunodeficiency virus (HIV)
Flucytosine
HIV Infections
Induction Phase
Review
Meningitis, Cryptococcal
medicine.disease_cause
Ambisome
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Amphotericin B
advanced HIV disease
medicine
Humans
030212 general & internal medicine
General Pharmacology, Toxicology and Pharmaceutics
Intensive care medicine
Fluconazole
Cryptococcus neoformans
General Immunology and Microbiology
biology
business.industry
cryptococcal meningo-encephalitis
Articles
General Medicine
biology.organism_classification
3. Good health
AIDS
Cryptococcal meningitis
business
medicine.drug
Subjects
Details
- ISSN :
- 20461402
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- F1000Research
- Accession number :
- edsair.doi.dedup.....7db1369859ba20f6c81bde5e9fba089f