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Effects of two types of inactivity on the number of white blood cells in rats
- Source :
- European journal of applied physiology. 98(6)
- Publication Year :
- 2006
-
Abstract
- Prolonged inactivity is known to induce changes in responses of many physiological defense systems such as the hypothalamo-hypophyseal-adrenocortical axis, the sympathetic nervous system, and immuno-responsive systems. However, effects of various types of inactivity on immuno-responsive systems are still unknown. Therefore, the effects of two types of inactivity (immobilization: IMM and whole body suspension: WBS) on the number of white blood cells were studied in rats. Rats were divided into the control group and each inactivity group to compare the number of total white blood cells, lymphocytes, monocyte, neutrophil, eosinophil, and basophil during the experimental periods. Both IMM and WBS were maintained for 11 days. IMM markedly increased the number of total white blood cells, monocyte, neutrophil, and eosinophil in the 1st to 10th day. However, the number of total white blood cells, monocyte, neutrophil, and eosinophil during the experiment of WBS were characterized by the presence of a lag phase followed by the significant increased actions. IMM did not change the number of basophil during the experimental period. However, WBS increased the number of basophil in the 1st to 8th day to 2.8-4.8 times, compared with the values of the control. Both IMM and WBS did not change the number of lymphocytes. From these results, WBS increases the number of natural immunity cells without changing acquired immunity cells, and there are different responses in the number of total white blood cells, monocyte, neutrophil, eosinophil, and basophil between IMM and WBS.
- Subjects :
- Male
medicine.medical_specialty
Sympathetic nervous system
Physiology
Biology
Basophil
Motor Activity
Blood cell
Rats, Sprague-Dawley
Immobilization
Leukocyte Count
Physiology (medical)
Internal medicine
medicine
Animals
Orthopedics and Sports Medicine
Lymphocyte Count
Innate immune system
Weightlessness
Monocyte
Body Weight
Public Health, Environmental and Occupational Health
General Medicine
Organ Size
Eosinophil
Acquired immune system
Rats
White (mutation)
medicine.anatomical_structure
Endocrinology
Subjects
Details
- ISSN :
- 14396319
- Volume :
- 98
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European journal of applied physiology
- Accession number :
- edsair.doi.dedup.....7dce0d49b2036f6c9249a518f51abb33