THE DIAGNOSTIC EFFICACY AND SAFETY OF MACROCYCLIC GADOLINIUM-BASED MAGNETIC RESONANCE CONTRAST AGENTS

The paper provides information on the safety and diagnostic efficacy of macrocyclic magnetic resonance contrast agents, such as gadobutrol, gadoteridol, and gadoteric acid. It is concluded that the standard gadobutrol dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children, including by newborn infants and adults. Owing to the increased relaxivity and double concentration of gadolinium, gadobutrol, as compared to gadoteridol and gadoteric acid, has a higher diagnostic efficacy and pharmacoeconomic advantages.