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Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever
- Source :
- Rheumatology International. 38:83-87
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- PubMedID: 29143127 Familial Mediterranean fever is an autoinflammatory disorder characterized by recurrent fever and serositis. We aimed to describe serum vitamin B 12 and vitamin D levels and their correlation with self-reported sleep quality of pediatric FMF patients. Sixty-three children with FMF were enrolled to the study. Information on sleep quality was obtained using self-administration of Pittsburg Sleep Quality Index (PSQI). The patients were divided into subgroups depending on vitamin D serum concentrations: ? 20 and < 20 ng/ml. We also grouped patients according to their serum B 12 concentration: ? 200, < 200 pg/ml. B 12 levels were not correlated with PSQI scores, whereas significant correlation was found between vitamin D and total PSQI scores and daytime sleepiness. Total PSQI score, sleep disorders and daytime sleepiness sub-scores were statistically high in patients with serum D vitamin levels below 20 ng/ml. Sleep efficiency was found lower in patients with serum B 12 levels below 200 pg/ml. B 12 may have a positive role on effective sleep. More importantly, we suggest that vitamin D is protective against sleep disorders and poor sleep, it may also improve daytime activities. © 2017, Springer-Verlag GmbH Germany, part of Springer Nature.
- Subjects :
- 0301 basic medicine
Vitamin
medicine.medical_specialty
Vitamin B-12
Immunology
Familial Mediterranean fever
Affect (psychology)
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
25 Hydroxycholecalciferol
0302 clinical medicine
Rheumatology
Internal medicine
Vitamin D and neurology
Immunology and Allergy
Medicine
Vitamin B12
Children
030203 arthritis & rheumatology
business.industry
medicine.disease
Sleep in non-human animals
humanities
Vitamin B 12
030104 developmental biology
Endocrinology
chemistry
Sleep
business
Serositis
Subjects
Details
- ISSN :
- 1437160X and 01728172
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Rheumatology International
- Accession number :
- edsair.doi.dedup.....7dd8ad873d9da77688dcb5cfc4894d49