Back to Search
Start Over
Role of Inflammation in Vascular Disease-Related Perivascular Adipose Tissue Dysfunction
- Source :
- Frontiers in Endocrinology, Vol 12 (2021), Frontiers in Endocrinology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Perivascular adipose tissue (PVAT) is the connective tissue around most blood vessels throughout the body. It provides mechanical support and maintains vascular homeostasis in a paracrine/endocrine manner. Under physiological conditions, PVAT has anti-inflammatory effects, improves free fatty acid metabolism, and regulates vasodilation. In pathological conditions, PVAT is dysfunctional, secretes many anti-vasodilator factors, and participates in vascular inflammation through various cells and mediators; thus, it causes dysfunction involving vascular smooth muscle cells and endothelial cells. Inflammation is an important pathophysiological event in many vascular diseases, such as vascular aging, atherosclerosis, and hypertension. Therefore, the pro-inflammatory crosstalk between PVAT and blood vessels may comprise a novel therapeutic target for the prevention and treatment of vascular diseases. In this review, we summarize findings concerning PVAT function and inflammation in different pathophysiological backgrounds, focusing on the secretory functions of PVAT and the crosstalk between PVAT and vascular inflammation in terms of vascular aging, atherosclerosis, hypertension, diabetes mellitus, and other diseases. We also discuss anti-inflammatory treatment for potential vascular diseases involving PVAT.
- Subjects :
- Pathology
medicine.medical_specialty
Vascular smooth muscle
endocrine
Endocrinology, Diabetes and Metabolism
Adipose tissue
Connective tissue
Inflammation
Vasodilation
Review
Diseases of the endocrine glands. Clinical endocrinology
crosstalk
Paracrine signalling
Endocrinology
Diabetes mellitus
perivascular adipose tissue
medicine
Animals
Humans
Vascular disease
business.industry
medicine.disease
RC648-665
medicine.anatomical_structure
Adipose Tissue
inflammation
Blood Vessels
vascular diseases
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....7ddbb2af12105712f3e81a1cb8c15a34