Back to Search
Start Over
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
- Source :
- Molecular psychiatry, 26(9), 5124-5139. Nature Publishing Group, Molecular Psychiatry, Molecular Psychiatry, 26, 5124-5139, Molecular Psychiatry, 26(9), 5124-5139. Nature Publishing Group, Han, L K M, Dinga, R, Hahn, T, Ching, C R K, Eyler, L T, Aftanas, L, Aghajani, M, Aleman, A, Baune, B T, Berger, K, Brak, I, Filho, G B, Carballedo, A, Connolly, C G, Couvy-duchesne, B, Cullen, K R, Dannlowski, U, Davey, C G, Dima, D, Duran, F L S, Enneking, V, Filimonova, E, Frenzel, S, Frodl, T, Fu, C H Y, Godlewska, B R, Gotlib, I H, Grabe, H J, Groenewold, N A, Grotegerd, D, Gruber, O, Hall, G B, Harrison, B J, Hatton, S N, Hermesdorf, M, Hickie, I B, Ho, T C, Hosten, N, Jansen, A, Kähler, C, Kircher, T, Klimes-dougan, B, Krämer, B, Krug, A, Lagopoulos, J, Leenings, R, Macmaster, F P, Macqueen, G, Mcintosh, A, Mclellan, Q, Mcmahon, K L, Medland, S E, Mueller, B A, Mwangi, B, Osipov, E, Portella, M J, Pozzi, E, Reneman, L, Repple, J, Rosa, P G P, Sacchet, M D, Sämann, P G, Schnell, K, Schrantee, A, Simulionyte, E, Soares, J C, Sommer, J, Stein, D J, Steinsträter, O, Strike, L T, Thomopoulos, S I, Van Tol, M, Veer, I M, Vermeiren, R R J M, Walter, H, Van Der Wee, N J A, Van Der Werff, S J A, Whalley, H, Winter, N R, Wittfeld, K, Wright, M J, Wu, M, Völzke, H, Yang, T T, Zannias, V, De Zubicaray, G I, Zunta-soares, G B, Abé, C, Alda, M, Andreassen, O A, Bøen, E, Bonnin, C M, Canales-rodriguez, E J, Cannon, D, Caseras, X, Chaim-avancini, T M, Elvsåshagen, T, Favre, P, Foley, S F, Fullerton, J M, Goikolea, J M, Haarman, B C M, Hajek, T, Henry, C, Houenou, J, Howells, F M, Ingvar, M, Kuplicki, R, Lafer, B, Landén, M, Machado-vieira, R, Malt, U F, Mcdonald, C, Mitchell, P B, Nabulsi, L, Otaduy, M C G, Overs, B J, Polosan, M, Pomarol-clotet, E, Radua, J, Rive, M M, Roberts, G, Ruhe, H G, Salvador, R, Sarró, S, Satterthwaite, T D, Savitz, J, Schene, A H, Schofield, P R, Serpa, M H, Sim, K, Soeiro-de-souza, M G, Sutherland, A N, Temmingh, H S, Timmons, G M, Uhlmann, A, Vieta, E, Wolf, D H, Zanetti, M V, Jahanshad, N, Thompson, P M, Veltman, D J, Penninx, B W J H, Marquand, A F, Cole, J H & Schmaal, L 2020, ' Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-0754-0, Molecular psychiatry 26(9), 5124-5139 (2021). doi:10.1038/s41380-020-0754-0, Molecular Psychiatry, 26, 5124-5139. Nature Publishing Group, Molecular psychiatry, Han, L KM, Dinga, R, Hahn, T, Ching, C, Eyler, L, Aftanas, L, Aghajani, M, Aleman, A, Baune, B, Berger, K, Brak, I, Filho, G B, Carballedo, A, Connolly, C, Couvy-Duchesne, B, Cullen, K, Dannlowski, U, Davey, C, Dima, D, Duran, F, Enneking, V, Filimonova, E, Frenzel, S, Frodl, T, Fu, C, Godlewska, B, Gotlib, I, Grabe, H, Groenewold, N, Grotegerd, D, Gruber, O, Hall, G, Harrison, B, Hatton, S, Hermesdorf, M, Hickie, I, Ho, T, Hosten, N, Jansen, A, Kahler, C, Kircher, T, Klimes-Dougan, B, Kramer, B, Krug, A, Lagopoulos, J, Leenings, R, MacMaster, F, MacQueen, G, McIntosh, A, McLellan, Q, McMahon, K, Medland, S, Mueller, B, Mwangi, B, Osipov, E, Portella, M, Pozzi, E, Reneman, L, Repple, J, Rosa, P, Sacchet, M, Saemann, P, Schnell, K, Schrantee, A, Simulionyte, E, Soares, J, Sommer, J, Stein, D, Steinstrater, O, Strike, L, Thomopoulos, S, Tol, M-J V, Veer, I, Vermeiren, R, Walter, H, Wee, N V D, Werff, S V D, Whalley, H, Winter, N, Wittfeld, K, Wright, M, Wu, M-J, Volzke, H, Yang, T, Zannias, V, Zubicaray, G D, Zunta-Soares, G, Abe, C, Alda, M, Andreassen, O, Boen, E, Bonnin, C, Canales-Rodriguez, E, Cannon, D, Caseras, X, Chaim-Avancini, T, Elvsashagen, T, Favre, P, Foley, S, Fullerton, J, Goikolea, J, Haarman, B, Hajek, T, Henry, C, Houenou, J, Howells, F, Ingvar, M, Kuplicki, R, Lafer, B, Landen, M, Machado-Vieira, R, Malt, U, McDonald, C, Mitchell, P, Nabulsi, L, Otaduy, M, Overs, B, Polosan, M, Pomarol-Clotet, E, Radua, J, Rive, M, Roberts, G, Ruhe, H, Salvador, R, Sarro, S, Satterthwaite, T, Savitz, J, Schene, A, Schofield, P, Serpa, M, Sim, K, Soeiro-de-Souza, M, Sutherland, A, Temmingh, H, Timmons, G, Uhlmann, A, Vieta, E, Wolf, D, Zanetti, M, Jahanshad, N, Thompson, P, Veltman, D, Penninx, B, Marquand, A, Cole, J & Schmaal, L 2019, ' Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group ', Biorxiv . https://doi.org/10.1101/560623, Han, L K M, Dinga, R, Hahn, T, Ching, C R K, Eyler, L T, Aftanas, L, Aghajani, M, Aleman, A, Baune, B T, Berger, K, Brak, I, Filho, G B, Carballedo, A, Connolly, C G, Couvy-Duchesne, B, Cullen, K R, Dannlowski, U, Davey, C G, Dima, D, Duran, F L S, Enneking, V, Filimonova, E, Frenzel, S, Frodl, T, Fu, C H Y, Godlewska, B R, Gotlib, I H, Grabe, H J, Groenewold, N A, Grotegerd, D, Gruber, O, Hall, G B, Harrison, B J, Hatton, S N, Hermesdorf, M, Hickie, I B, Ho, T C, Hosten, N, Jansen, A, Kähler, C, Kircher, T, Klimes-Dougan, B, Krämer, B, Krug, A, Lagopoulos, J, Leenings, R, MacMaster, F P, MacQueen, G, McIntosh, A, McLellan, Q, McMahon, K L, Medland, S E, Mueller, B A, Mwangi, B, Osipov, E, Portella, M J, Pozzi, E, Reneman, L, Repple, J, Rosa, P G P, Sacchet, M D, Sämann, P G, Schnell, K, Schrantee, A, Simulionyte, E, Soares, J C, Sommer, J, Stein, D J, Steinsträter, O, Strike, L T, Thomopoulos, S I, van Tol, M J, Veer, I M, Vermeiren, R R J M, Walter, H, van der Wee, N J A, van der Werff, S J A, Whalley, H, Winter, N R, Wittfeld, K, Wright, M J, Wu, M J, Völzke, H, Yang, T T, Zannias, V, de Zubicaray, G I, Zunta-Soares, G B, Abé, C, Alda, M, Andreassen, O A, Bøen, E, Bonnin, C M, Canales-Rodriguez, E J, Cannon, D, Caseras, X, Chaim-Avancini, T M, Elvsåshagen, T, Favre, P, Foley, S F, Fullerton, J M, Goikolea, J M, Haarman, B C M, Hajek, T, Henry, C, Houenou, J, Howells, F M, Ingvar, M, Kuplicki, R, Lafer, B, Landén, M, Machado-Vieira, R, Malt, U F, McDonald, C, Mitchell, P B, Nabulsi, L, Otaduy, M C G, Overs, B J, Polosan, M, Pomarol-Clotet, E, Radua, J, Rive, M M, Roberts, G, Ruhe, H G, Salvador, R, Sarró, S, Satterthwaite, T D, Savitz, J, Schene, A H, Schofield, P R, Serpa, M H, Sim, K, Soeiro-de-Souza, M G, Sutherland, A N, Temmingh, H S, Timmons, G M, Uhlmann, A, Vieta, E, Wolf, D H, Zanetti, M V, Jahanshad, N, Thompson, P M, Veltman, D J, Penninx, B W J H, Marquand, A F, Cole, J H & Schmaal, L 2021, ' Brain aging in major depressive disorder : results from the ENIGMA major depressive disorder working group ', Molecular Psychiatry, vol. 26, no. 9, pp. 5124-5139 . https://doi.org/10.1038/s41380-020-0754-0, Molecular Psychiatry, 26, 9, pp. 5124-5139, Biorxiv. Cold Spring Harbor Laboratory Press, Biorxiv
- Publication Year :
- 2021
-
Abstract
- BackgroundMajor depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in MDD patients, and whether this process is associated with clinical characteristics in a large multi-center international dataset.MethodsWe performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 29 samples worldwide. Normative brain aging was estimated by predicting chronological age (10-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 1,147 male and 1,386 female controls from the ENIGMA MDD working group. The learned model parameters were applied to 1,089 male controls and 1,167 depressed males, and 1,326 female controls and 2,044 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain predicted age difference (brain-PAD).FindingsOn average, MDD patients showed a higher brain-PAD of +0.90 (SE 0.21) years (Cohen’s d=0.12, 95% CI 0.06-0.17) compared to controls. Relative to controls, first-episode and currently depressed patients showed higher brain-PAD (+1.2 [0.3] years), and the largest effect was observed in those with late-onset depression (+1.7 [0.7] years). In addition, higher brain-PAD was associated with higher self-reported depressive symptomatology (b=0.05, p=0.004).InterpretationThis highly powered collaborative effort showed subtle patterns of abnormal structural brain aging in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the predictive value of these brain-PAD estimates.FundingThis work was supported, in part, by NIH grants U54 EB020403 and R01 MH116147.
- Subjects :
- Adult
Male
medicine.medical_specialty
Aging
Adolescent
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
BF
Health outcomes
Article
Cellular and Molecular Neuroscience
03 medical and health sciences
Lateral ventricles
Young Adult
0302 clinical medicine
Atrophy
Internal medicine
medicine
Humans
ddc:610
Longitudinal Studies
Molecular Biology
diagnostic imaging [Brain]
Brain aging
Depression (differential diagnoses)
030304 developmental biology
Aged
0303 health sciences
Depressive Disorder, Major
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
business.industry
Depression
220 Statistical Imaging Neuroscience
Brain
Chronological age
Middle Aged
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
Increased risk
RC0321
Major depressive disorder
Female
Age of onset
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- ISSN :
- 13594184
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Molecular Psychiatry
- Accession number :
- edsair.doi.dedup.....7de37fdb9f3a26a46f81b7cfb235191c