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Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: A European Society of Thoracic Surgeons Thymic Working Group Study
- Source :
- European journal of cardiothoracic surgery, Eur J Cardiothorac Surg
- Publication Year :
- 2021
-
Abstract
- OBJECTIVES Resection of thymic tumours including the removal of both the tumour and the thymus gland (thymothymectomy; TT) is the procedure of choice and is recommended in most relevant articles in the literature. Nevertheless, in recent years, some authors have suggested that resection of the tumour (simple thymomectomy; ST) may suffice from an oncological standpoint in patients with early-stage thymoma who do not have myasthenia gravis (MG) (non-MG). The goal of our study was to compare the short- and long-term outcomes of ST versus TT in non-MG early-stage thymomas using the European Society of Thoracic Surgeons thymic database. METHODS A total of 498 non-MG patients with pathological stage I thymoma were included in the study. TT was performed in 466 (93.6%) of 498 patients who had surgery with curative intent; ST was done in 32 (6.4%). The completeness of resection, the rate of complications, the 30-day mortality, the overall recurrence and the freedom from recurrence were compared. We performed crude and propensity score-adjusted comparisons by surgical approach (ST vs TT). RESULTS TT showed the same rate of postoperative complications, 30-day mortality and postoperative length of stay as ST. The 5-year overall survival rate was 89% in the TT group and 55% in the ST group. The 5-year freedom from recurrence was 96% in the TT group and 79% in the ST group. CONCLUSION Patients with early-stage thymoma without MG who have a TT show significantly better freedom from recurrence than those who have an ST, without an increase in postoperative morbidity rate.
- Subjects :
- Survival
Thoracic
medicine.medical_treatment
Medizin
Extended thymectomy
Recurrence
Thymectomy
Thymoma
Thymomectomy
Thymothymomectomy
Humans
Neoplasm Recurrence, Local
Neoplasm Staging
Retrospective Studies
Thymus Gland
Myasthenia Gravis
Surgeons
Thymus Neoplasms
extended thymectomy
Neoplasm Recurrence
Local
Stage (cooking)
thymectomy
thymothymomectomy
Total thymectomy
Mortality rate
General Medicine
thymoma
thymomectomy
Cardiology and Cardiovascular Medicine
Corrigendum
Pulmonary and Respiratory Medicine
medicine.medical_specialty
recurrence
survival
medicine
Pathological
Group study
business.industry
medicine.disease
Myasthenia gravis
Surgery
Human medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 10107940
- Database :
- OpenAIRE
- Journal :
- European journal of cardiothoracic surgery, Eur J Cardiothorac Surg
- Accession number :
- edsair.doi.dedup.....7dea9e115b62edd85232e46df18148c0