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Enhanced expression of Galectin-3 in gestational diabetes
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 31:1791-1797
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background and aims Gestational diabetes mellitus (GDM), hyperglycemia diagnosed during pregnancy, is one of the most common medical complications of pregnancy, treated primarily by diet and pharmacotherapy, if indicated. It is well-established that GDM increases the risk of adverse pregnancy outcomes and long-term complications in mothers and infants. Galectin-3 (Gal-3) is important in processes of cell growth, differentiation, inflammation, and fibrosis. We evaluated Gal-3 expression in pregnancies complicated by GDM as a parameter that might explain how GDM influences early onset of future complications. Methods and results Forty-four women with GDM and 40 with normal pregnancy (NP) were recruited during delivery admission. Blood samples were obtained from parturients and umbilical cords blood, as well as placental tissue for analysis. Gal-3 mRNA expression was increased in maternal blood samples and placental tissue of women with GDM compared to NP. In GDM, Gal-3 mRNA was decreased in cord blood compared to maternal blood and placental tissue. Gal-3 GDM placental protein expression was increased compared to NP. Immunostaining revealed that Gal-3 is upregulated in GDM placental extravillous trophoblast. ELISA of Gal-3 maternal serum levels between GDM and NP were similar. Conclusion Gal-3 is strongly expressed at molecular levels (mRNA and protein expression) in GDM maternal blood and placental tissue, and decreased in cord blood. These findings highlight the role of the placenta in protecting the fetus from potential Gal-3 damage. Gal-3 expression at mRNA and protein levels might be influenced by diabetes, even if blood glucose is balanced by medication or diet.
- Subjects :
- Adult
medicine.medical_specialty
Complications of pregnancy
endocrine system diseases
Galectins
Placenta
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Pregnancy
Fibrosis
Diabetes mellitus
Internal medicine
Humans
Medicine
Maternal-Fetal Exchange
Fetus
Nutrition and Dietetics
business.industry
nutritional and metabolic diseases
Blood Proteins
Fetal Blood
medicine.disease
female genital diseases and pregnancy complications
Up-Regulation
Gestational diabetes
Diabetes, Gestational
medicine.anatomical_structure
Endocrinology
Case-Control Studies
Cord blood
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....7df6025caae67ec99a647194ea02a031