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Wound bed preparation with 10 percent phenytoin ointment increases the take of split-thickness skin graft in large diabetic ulcers
- Source :
- Younes, Nidal; Albsoul, Abla; Badran, Darwish; & Obedi, Salwan. (2006). Wound bed preparation with 10 percent phenytoin ointment increases the take of split-thickness skin graft in large diabetic ulcers. Dermatology Online Journal, 12(6). Retrieved from: http://www.escholarship.org/uc/item/98t188x0, Scopus-Elsevier
- Publication Year :
- 2006
- Publisher :
- eScholarship, University of California, 2006.
-
Abstract
- Healing of large diabetic foot ulcers may be difficult, particularly if the blood supply and chronic infection do not allow primary suturing. Split-thickness skin graft is a simple reconstructive technique used to close large wounds. Phenytoin is known to promote healing mainly by increasing granulation tissue formation. The effectiveness of topical phenytoin in wound-bed preparation (WBP) for split thickness skin grafting has been examined in 16 patients with large diabetic foot ulcers. All patients were treated with standard wound bed preparation including debridement of necrotic tissue. Topical phenytoin (10 % w/w ointment) was applied for 2-8 weeks prior to performance of autografting. Clinical and histologic evaluations were performed. The graft survival was 100 percent In twelve patients, 80-90 percent in three patients take and 60 percent in one patient. Neither local nor systemic side effects were observed. The authors conclude that phenytoin ointment is a safe and efficacious treatment to enhance the survival of split-thickness skin grafts in large chronic diabetic ulcers.
- Subjects :
- Phenytoin
medicine.medical_specialty
Debridement
business.industry
medicine.medical_treatment
Granulation tissue
Dermatology
General Medicine
medicine.disease
Diabetic foot
Surgery
Transplantation
medicine.anatomical_structure
Amputation
Wound bed preparation
medicine
Skin grafting
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Younes, Nidal; Albsoul, Abla; Badran, Darwish; & Obedi, Salwan. (2006). Wound bed preparation with 10 percent phenytoin ointment increases the take of split-thickness skin graft in large diabetic ulcers. Dermatology Online Journal, 12(6). Retrieved from: http://www.escholarship.org/uc/item/98t188x0, Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....7e040b7dd6281f915547d5a9ddbea09b