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Prospective randomized clinical trial of two drug delivery pathway in the treatment of inoperable advanced pancreatic carcinoma
- Source :
- Chinese journal of digestive diseases. 7(1)
- Publication Year :
- 2006
-
Abstract
- OBJECTIVES: Evaluate the effect of an implanted percutaneous left subclavian artery port-catheter drug delivery system for regional chemotherapy of inoperable pancreatic carcinoma. METHODS: One hundred and forty patients with inoperable pancreatic carcinoma were enrolled and randomized into two groups to receive the FAM regimen on a 6-day cycle at 1-month intervals: 70 patients in the regional interventional chemotherapy group in which treatment was infused directly into the common hepatic artery, and 70 patients who received the same chemotherapy regimen via the peripheral vein. RESULT: In the interventional chemotherapy group, there were 5 cases of complete remission (CR) and 49 cases of partial remission (PR), giving a response rate (CR+PR) of 77.1%; pain control was effective in 95.7% cases; survival time was 3–34 months (median 13.5). There was no case of CR in the systemic chemotherapy group, and 25 cases of PR, giving a response rate of 35.7%; pain control was effective in 35.7%, and survival time was 1–13 months (median 6.2). The differences between the two groups in response rate and survival were statistically significant (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Antimetabolites, Antineoplastic
Nausea
medicine.medical_treatment
Mitomycin
law.invention
Drug Delivery Systems
Randomized controlled trial
law
medicine.artery
Antineoplastic Combined Chemotherapy Protocols
Medicine
Humans
Infusions, Intra-Arterial
Prospective Studies
Vein
FAM Regimen
Aged
Neoplasm Staging
Chemotherapy
Antibiotics, Antineoplastic
Common hepatic artery
business.industry
Gastroenterology
Middle Aged
Chemotherapy regimen
Survival Analysis
Surgery
Pancreatic Neoplasms
medicine.anatomical_structure
Treatment Outcome
Doxorubicin
Vomiting
Female
Fluorouracil
medicine.symptom
business
Subjects
Details
- ISSN :
- 14439611
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Chinese journal of digestive diseases
- Accession number :
- edsair.doi.dedup.....7e06ae82a593666f670472e0bf5cf932