257 Improving nutrition for pediatric cystic fibrosis patients

Objectives: Evaluation of tolerance and clinical efficacy of nutritional support with high energy milk formula in Russian young children with CF. Methods: During the planned hospitalization (average 12.6 days) 30 children aged 1.5−10 years old with CF and pancreatic insufficiency were given milk formula (protein 4.2 g, fat 7.7 g, carbohydrates 16.39 g, energy 150 kcal/100ml, enriched with fiber and prebiotic, vanilla taste) up to 200ml/day (1−3 years), 300ml (4−6 years), 400ml (>6 years) between meals, with addition of 2500 IE (lipase) of Creon to each 100ml of formula. Results: Four (13.3%) children rejected. 26 (86.7%) of children accepted the formula well, no allergic reactions, intolerance or stool worsening. 23 (88.5%) patients gained weight by av. 415 g, with maximum gain of 2.3 kg in a boy who received formula the longest (24 days). Skin fold thickness increased in 23 (88.5%) children by average +0.364mm over triceps, in 17 (65.4%) by av. +0.372mm over biceps, and upper arm muscle circumference increased in (84.6%) by av. +0.332 cm. The daily Creon dose per 1 kg of body weight decreased in 11 (42.3%) cases because of patient’s weight gain, and increased insignificantly in the rest. Conclusions: The formula was well-tolerated and had an overall positive influence on the nutritive status indices, despite of the short terms of application and fact that Creon daily dose wasn’t significantly increased. Thus, it can be used as the additional feeding source in the most of young children with CF. However, taking into account the cases of refusal and peculiarities of taste preferences, children with CF require wider taste spectrum of products for additional feeding.