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Liquid biopsy in diffuse large B-cell lymphoma: utility in cell origin determination and survival prediction in Chinese patients
- Source :
- Leukemia & Lymphoma. 63:608-617
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- The utility of circulating tumor DNA (ctDNA) in classifying the cell origin of diffuse large B-cell lymphoma (DLBCL) has not been explored in the Chinese population. In this study, we aimed to investigate the genetic characteristics of DLBCL based on both tumor and ctDNA sequencing and to assess the predictive value of ctDNA in DLBCL. A targeted sequencing panel of 413 genes was applied to tumor biopsies and paired plasma samples obtained from 30 patients with DLBCL before therapeutic intervention (pretreatment). The concordance between plasma genotyping classification and traditional cell-of-origin classification using tumor tissue was 80.0% (20/25). Patients with higher baseline plasma ctDNA levels had poorer survival compared to those with lower ctDNA levels (2-year progression survival rate: 40.0% vs. 80.0%, p = 0.011; 5-year overall survival rate: 30.5% vs. 70.0%, p = 0.004). Collectively, our results demonstrated that pretreatment ctDNA analysis could assist origin determination and prognosis prediction clinically.
- Subjects :
- Oncology
China
Cancer Research
medicine.medical_specialty
Cell of origin
Concordance
Cell
Circulating Tumor DNA
Internal medicine
Biomarkers, Tumor
medicine
Humans
Liquid biopsy
Survival rate
Genotyping
business.industry
Liquid Biopsy
Hematology
Prognosis
medicine.disease
Lymphoma
medicine.anatomical_structure
Mutation
Lymphoma, Large B-Cell, Diffuse
business
Diffuse large B-cell lymphoma
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....7e310c2ca1b1cc5b8b480f75c394f78d