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Analysis of the effect of occupational exposure to asbestos based on threshold regression modeling of case-control data
- Source :
- Biostatistics, Biostatistics, 2014, 15 (2), pp.327-340. ⟨10.1093/biostatistics/kxt042⟩, Biostatistics, Oxford University Press (OUP), 2014, 15 (2), pp.327-340. ⟨10.1093/biostatistics/kxt042⟩, Biostatistics, Oxford University Press (OUP), 2014, 15 (2), pp.327-340. 〈https://academic.oup.com/biostatistics/〉. 〈10.1093/biostatistics/kxt042 〉
- Publication Year :
- 2013
-
Abstract
- International audience; We analyze the effect of occupational exposure to asbestos on the occurrence of lung cancer based on arecent French case–control (CC) study. We build a large collection of threshold regression models, dataadaptivelyselect a better model by CC-weighted likelihood-based cross-validation and then fit this bettermodel by CC-weighted maximum likelihood. The CC-weighting allows us to draw valid inferences fromCC data without relying on a logistic regression. This is possible because the joint distribution of theindicator of being a case and matching variable is available beforehand owing to two studies independentfrom our data set. The implications of the fitted model in terms of years of life free of lung cancer lost dueto the exposure to asbestos are discussed.
- Subjects :
- Statistics and Probability
Male
Matching (statistics)
Lung Neoplasms
Computer science
[SDV]Life Sciences [q-bio]
[SDV.CAN]Life Sciences [q-bio]/Cancer
Logistic regression
medicine.disease_cause
01 natural sciences
Asbestos
Cross-validation
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Case–control (CC) study
010104 statistics & probability
03 medical and health sciences
0302 clinical medicine
[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST]
Joint probability distribution
Occupational Exposure
Statistics
medicine
Humans
[ MATH.MATH-ST ] Mathematics [math]/Statistics [math.ST]
0101 mathematics
Likelihood Functions
Models, Statistical
[ SDV ] Life Sciences [q-bio]
Regression analysis
General Medicine
Threshold regression model (TR)
Data set
Variable (computer science)
030220 oncology & carcinogenesis
Case-Control Studies
Data Interpretation, Statistical
Regression Analysis
Occupational exposure to asbestos
Female
Statistics, Probability and Uncertainty
Subjects
Details
- ISSN :
- 14684357 and 14654644
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biostatistics (Oxford, England)
- Accession number :
- edsair.doi.dedup.....7e3ba91a029ffa1ee24883551bc173a8