Back to Search
Start Over
Cognitive Outcomes After Heart Valve Surgery: A Systematic Review and Meta-Analysis
- Source :
- Journal of the American Geriatrics Society. 66(12)
- Publication Year :
- 2018
-
Abstract
- Objectives To summarize evidence on cognitive outcomes after heart valve surgery; secondary aim, to examine whether aortic and mitral valve surgery are associated with different cognitive outcomes. Design Preferred Reporting Items for Systematic Reviews and Meta‐Analyses systematic review and meta‐analysis. Setting Cardiac surgery. Participants Individuals undergoing heart valve surgery. Measurements We searched MEDLINE, EMBASE, and PsycINFO for peer‐reviewed reports of individuals undergoing heart valve surgery who underwent pre‐ and postoperative cognitive assessment. Our initial search returned 1,475 articles, of which 12 were included. Postoperative cognitive results were divided into those from 1 week to 1 month (early outcomes, npooled = 450) and from 2 to 6 months (intermediate outcomes; npooled = 722). No studies with longer‐term outcomes were identified. Results Subjects had moderate early cognitive decline from baseline (Becker mean gain effect size (ES)=−0.39 ± 0.27) that improved slightly by 2 to 6 months (ES=–0.25 ± 0.38). Individuals undergoing aortic valve surgery—who were older on average than those undergoing mitral valve surgery (68 vs 57)—had greater early cognitive decline than those undergoing mitral valve surgery (ES=–0.68 vs −0.12), but both cohorts had similar decline 2 to 6 months postoperatively (ES=–0.27 vs −0.20). Conclusions Heart valve surgery is associated with cognitive decline over the 6 months after surgery, but outcomes beyond 6 months are unclear. These findings highlight the cognitive vulnerability of this population, especially older adults with aortic stenosis. © 2018 American Geriatrics Society and Wiley Periodicals, Inc. J Am Geriatr Soc 66:2327–2334, 2018
- Subjects :
- Aortic valve
medicine.medical_specialty
Population
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Risk Factors
medicine
Humans
Cognitive Dysfunction
030212 general & internal medicine
Cognitive decline
Cardiac Surgical Procedures
education
Aged
Geriatrics
Cognitive vulnerability
education.field_of_study
business.industry
valvular heart disease
Mitral Valve Insufficiency
Aortic Valve Stenosis
medicine.disease
Cardiac surgery
medicine.anatomical_structure
Aortic Valve
Physical therapy
Geriatrics and Gerontology
business
Postoperative cognitive dysfunction
Subjects
Details
- ISSN :
- 15325415
- Volume :
- 66
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American Geriatrics Society
- Accession number :
- edsair.doi.dedup.....7e40f515c7be2458b794b7befa0e37e2