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Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy
- Source :
- Therapeutic delivery. 10(4)
- Publication Year :
- 2019
-
Abstract
- Aim: The current study aims to co-deliver docetaxel (DTX) and alpha-lipoic acid (ALA) using solid lipid nanoparticles (SLNs) as a carrier for the treatment of breast cancer. Methods: Computational analysis was used to screen different solid lipids as carriers, following which SLNs were prepared and characterized. Furthermore, antioxidant activity assays and cell culture studies were performed. Results: In vitro assessment in 4T1 (murine mammary carcinoma) and MCF-7 (human breast adenocarcinoma) cells revealed enhanced efficacy of the co-loaded SLNs as compared with free drugs and single drug-loaded SLNs. Increased apoptosis following treatment with DTX-ALA co-loaded SLN was also observed. Conclusion: The developed SLNs showed significantly higher uptake efficiency along with improved cytotoxic and apoptotic potential indicating the usefulness of this combination.
- Subjects :
- Alpha-Lipoic Acid
Cancer therapy
Pharmaceutical Science
Nanoparticle
Antineoplastic Agents
Apoptosis
Breast Neoplasms
Mammary Neoplasms, Animal
02 engineering and technology
Docetaxel
Adenocarcinoma
030226 pharmacology & pharmacy
03 medical and health sciences
Mice
0302 clinical medicine
Breast cancer
Cell Line, Tumor
Solid lipid nanoparticle
medicine
Animals
Humans
Co delivery
Drug Carriers
Thioctic Acid
Chemistry
021001 nanoscience & nanotechnology
medicine.disease
Lipids
body regions
Cancer research
MCF-7 Cells
Nanoparticles
Female
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 20416008
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Therapeutic delivery
- Accession number :
- edsair.doi.dedup.....7e5c27a0ea180fe0d7994d7f86903d14