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DED or alive: assembly and regulation of the death effector domain complexes
- Source :
- Riley, JS, Malik, A, Holohan, C & Longley, DB 2015, ' DED or alive: assembly and regulation of the death effector domain complexes. ', Cell, Death & Disease, vol. 6, no. e1866, e1866 . https://doi.org/10.1038/cddis.2015.213, Europe PubMed Central, Cell Death & Disease
- Publication Year :
- 2015
-
Abstract
- Death effector domains (DEDs) are protein–protein interaction domains initially identified in proteins such as FADD, FLIP and caspase-8 involved in regulating apoptosis. Subsequently, these proteins have been shown to have important roles in regulating other forms of cell death, including necroptosis, and in regulating other important cellular processes, including autophagy and inflammation. Moreover, these proteins also have prominent roles in innate and adaptive immunity and during embryonic development. In this article, we review the various roles of DED-containing proteins and discuss recent developments in our understanding of DED complex formation and regulation. We also briefly discuss opportunities to therapeutically target DED complex formation in diseases such as cancer.
- Subjects :
- Models, Molecular
Cancer Research
Programmed cell death
Fas-Associated Death Domain Protein
Necroptosis
Immunology
Antineoplastic Agents
Apoptosis
Review
Q1
Mice
Cellular and Molecular Neuroscience
SDG 3 - Good Health and Well-being
Neoplasms
Autophagy
Animals
Humans
Protein Interaction Domains and Motifs
FADD
Adaptor Proteins, Signal Transducing
Caspase 8
Clinical Trials as Topic
biology
Effector
Cell Biology
Acquired immune system
Cell biology
Gene Expression Regulation, Neoplastic
biology.protein
Death effector domain
Signal transduction
Protein Binding
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Database :
- OpenAIRE
- Journal :
- Riley, JS, Malik, A, Holohan, C & Longley, DB 2015, ' DED or alive: assembly and regulation of the death effector domain complexes. ', Cell, Death & Disease, vol. 6, no. e1866, e1866 . https://doi.org/10.1038/cddis.2015.213, Europe PubMed Central, Cell Death & Disease
- Accession number :
- edsair.doi.dedup.....7e5ef9c2cce0f127fe9e3ac536db32e6