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Validación de un modelo de predicción pronóstico de complicaciones postquirúrgicas en pacientes pediátricos con apendicitis perforada sometidos a apendicectomía por laparoscopia
- Source :
- Blumfield E, Yang D, Grossman J. Scoring system for differentiating perforated and non-perforated pediatric appendicitis. Emerg Radiol. 2017;24(5):547–54., Marzuillo P. Appendicitis in children less than five years old: A challenge for the general practitioner. World J Clin Pediatr. 2015;4(2):19., Jonas CE, Cimino F, Hulsopple C. Cochrane for Clinicians Putting Evidence into Practice Procalcitonin to Guide Antibiotic Therapy in Acute Respiratory Infections Clinical Question Can using procalcitonin levels help guide antibi-otic stewardship for patients with acute respira-tory infec. Am Fam Physician [Internet]. 2018;98(1):25–33. DOI: 10.1016/S0002-838X(18)30204-1., Rentea RM, Peter SDS, Snyder CL. Pediatric appendicitis: state of the art review. Pediatr Surg Int. 2017;33(3):269–83., Newman KD. When Appendicitis Is Suspected in OBJECTIVES. Radiographics. 2001;5056:247–62., Low ZX, Bonney GK, So JBY, Loh DL, Ng JJ. Laparoscopic versus open appendectomy in pediatric patients with complicated appendicitis: a meta-analysis. Surg Endosc [Internet]. 2019;0(0):0. DOI: 10.1007/s00464-019-06709-x, American College of Radiology Suspected Physical Abuse – Child. 2016;1–15., Peter SDS, Sharp SW, Holcomb GW, Ostlie DJ. An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. J Pediatr Surg [Internet]. 2008;43(12):2242–5. DOI: 10.1016/j.jpedsurg.2008.08.051, Buckius MT, McGrath B, Monk J, Grim R, Bell T, Ahuja V. Changing epidemiology of acute appendicitis in the United States: Study period 1993-2008. J Surg Res [Internet]. 2012;175(2):185–90. DOI: 10.1016/j.jss.2011.07.017, Min. Salud MDSYPS. Análisis de Situación de Salud de Poblaciones Diferenciales Relevantes Ministerio de Salud y Protección Social Dirección de Epidemiología y Demografía Grupo ASIS. 2013;1–87., Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: Modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015;386(10000):1278–87., Li HM, Yeh LR, Huang YK, Hsieh MY, Yu KH, Kuo CF. Familial Risk of Appendicitis: A Nationwide Population Study. J Pediatr [Internet]. 2018;203:330-335.e3. DOI: 10.1016/j.jpeds.2018.07.071, Benabbas R, Hanna M, Shah J, Sinert R. Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point-of-care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta-analysis. Acad Emerg Med. 2017;24(5):523–51., Dahabreh IJ, Adam GP, Halladay CW, Steele DW, Daiello LA, Wieland LS, et al. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis. Diagnosis Right Low Quadr Pain Suspected Acute Append [Internet]. 2015;(157). PMID: 27054223 NBK355441., Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen J. Discriminative Accuracy of Novel and Traditional Biomarkers in Children with Suspected Appendicitis Adjusted for Duration of Abdominal Pain. 2009;377(2):364–77., Riaz N, Wolden SL, Gelblum DY, Eric J. Discovery and validation of urine markers of acute pediatric appendicitis using high-Accuracy mass spectrometry. 2016;118(24):6072–8. DOI: 10.1016/j.annemergmed.2009.04.020., Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen J. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. 2009;377(2):364–77. DOI: 10.1038/mi.2008.13., Groselj-Grenc M, Repse S, Dolenc-Strazar Z, Hojker S, Derganc M. Interleukin-6 and lipopolysaccharide-binding protein in acute appendicitis in children. Scand J Clin Lab Invest. 2007;67(2):197–206., Rivera-Chavez FA, Peters-Hybki DL, Barber RC, Lindberg GM, Jialal I, Munford RS, et al. Innate immunity genes influence the severity of acute appendicitis. Ann Surg. 2004;240(2):269–77., Andersson REB. Meta-analysis of the clinical and laboratory diagnosis of appendicitis. Br J Surg. 2004;91(1):28–37., Ebell MH, Shinholser J. What are the most clinically useful cutoffs for the alvarado and pediatric appendicitis scores? a systematic review. Ann Emerg Med [Internet]. 2014;64(4):365-372.e2. DOI: 10.1016/j.annemergmed.2014.02.025., Z. P, S. R, I. M, I. J. Prospective validation of Alvarado score and pediatric appendicitis score for the diagnosis of acute appendicitis in children. Pediatr Emerg Care [Internet]. 2015;31(3):164–8. DOI: 10.1097/PEC.0000000000000375, Khanafer I, Martin DA, Mitra TP, Eccles R, Brindle ME, Nettel-Aguirre A, et al. Test characteristics of common appendicitis scores with and without laboratory investigations: A prospective observational study. BMC Pediatr [Internet]. 2016;16(1):1–8. DOI: 10.1186/s12887-016-0687-6., Andersson M, Andersson RE. The appendicitis inflammatory response score: A tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008;32(8):1843–9., Castro SMMD, Ünlü Ç, Steller EP, Van Wagensveld BA, Vrouenraets BC. Evaluation of the appendicitis inflammatory response score for patients with acute appendicitis. World J Surg. 2012;36(7):1540–5., Adibe OO, Muensterer OJ, Georgeson KE, Harmon CM. Severity of appendicitis correlates with the pediatric appendicitis score. Pediatr Surg Int. 2011;27(6):655–8., Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002;37(6):877–81., Alvarado A. A Practical Score for the Early Diagnosis of Acute Appendicitis. Ann Emerg Med. 1986;15(5):557–64., Florence M, Flum DR, Jurkovich GJ, Lin P, Steele SR, Symons RG, et al. Negative appendectomy and imaging accuracy in the washington state surgical care and outcomes assessment program. Ann Surg. 2008;248(4):557–62., S.J. D, A. K. Point-of-Care Ultrasound Integrated Into a Staged Diagnostic Algorithm for Pediatric Appendicitis. Pediatr Emerg Care [Internet]. 2016;00(00):1–7. DOI: 10.1097%2FPEC.0000000000000773., Depinet H, von Allmen D, Towbin A, Hornung R, Ho M, Alessandrini E. Risk Stratification to Decrease Unnecessary Diagnostic Imaging for Acute Appendicitis. Pediatrics. 2016;138(3):e20154031–e20154031., Elikashvili I, Tay ET, Tsung JW. The effect of point-of-care ultrasonography on emergency department length of stay and computed tomography utilization in children with suspected appendicitis. Acad Emerg Med. 2014;21(2):163–70., Kearl YL, Claudius I, Behar S, Cooper J, Dollbaum R, Hardasmalani M, et al. Accuracy of Magnetic Resonance Imaging and Ultrasound for Appendicitis in Diagnostic and Nondiagnostic Studies. Acad Emerg Med. 2016;23(2):179–85, Rentea RM, St. Peter SD. Contemporary Management of Appendicitis in Children. Adv Pediatr [Internet]. 2017;64(1):225–51. DOI: 10.1016/j.yapd.2017.03.008., Mandeville K, Monuteaux M, Pottker T, Bulloch B. Effects of timing to diagnosis and appendectomy in pediatric appendicitis. Pediatr Emerg Care. 2015;31(11):753–8., Emily S, Elkady S, Shbat L, Youssef F, Baird R, Laberge J M, Shaw K. Determinants of postoperative abscess occurrence and percutaneous drainage in children with perforated appendicitis. Pediatric surgery international. 2014; 30(12), 1265-1271., Fraser JD, Aguayo P, Sharp S W, Snyder C L, Holcomb III GW, Ostlie DJ, Peter S. Physiologic predictors of postoperative abscess in children with perforated appendicitis: subset analysis from a prospective randomized trial. Surgery. 2010;147(5), 729-732., Frongia G, Mehrabi A, Ziebell L, Schenk JP, Günther P. Predicting postoperative complications after pediatric perforated appendicitis. Journal of Investigative Surgery. 2016; 29(4), 185-194., Henry MC, Walker A, Silverman BL, Gollin G, Islam S, Sylvester K, Moss RL. Risk factors for the development of abdominal abscess following operation for perforated appendicitis in children: a multicenter case-control study. Archives of surgery.2007;142(3), 236-241., Lodwick DL, Cooper JN, Kenney B, Deans KJ, Minneci P C, Thakkar RK. Lymphocyte depression as a predictor of postoperative intraabdominal abscess after appendectomy in children. Journal of pediatric surgery.2017;52(1), 93-97, Pathak IS, Sayed IA, Wise L, Sippel M, Hernandez LL, Mulla ZD. Predictors of a Prolonged Length of Stay in Children with Perforated Appendicitis. Southern medical journal. 2016;109(4), 230-235., Simundi c A-M. Measures of diagnostic accuracy: basic definitions. Med Biol Sci 2008;22:61-5., Steyerberg, E. W. Clinical prediction models. 2019. Springer International Publishing., Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
- Publication Year :
- 2020
- Publisher :
- Universidad del Rosario, 2020.
-
Abstract
- La apendicitis aguda es la primera causa de dolor abdominal en niños, la primera causa de muerte por sepsis de origen abdominal y la emergencia quirúrgica más frecuente en esta población, actualmente, no existe una herramienta que permita identificar aquellos pacientes con riesgo de complicaciones postapendicectomia, es por eso, que se desarrolló un modelo de predicción pronostica de complicaciones en pacientes pediátricos que han sido intervenidos quirúrgicamente para el manejo de apendicitis perforada. Este estudio se realizo en dos fases siendo la primera relacionada a la búsqueda de las variables independientes predictoras de complicaciones postquirurgícas para apendicitis perforada en la población estudiada y la segunda fase el desarrollo del modelo y su validación interna, finalmente, se obtuvo un modelo con valores de desempeño bastantes aceptables y una alta capacidad discriminatoria mayor 80% , igualmente, la validación interna mostró una buena extrapolación del modelo a otras variables dado que el optimismo fue bajo. Acute appendicitis is the main cause of abdominal pain in children, the first cause of death from abdominal sepsis and the most frequent surgical emergency in this population. Nowadays, there is no tool to identify those patients at risk of post-appendectomy complications. Hence, a prognostic prediction model for complications was developed in pediatric patients who have undergone surgery to manage perforated appendicitis. This study was carried out in two phases, the first related to figure out the independent variables predictive of post-surgical complications for perforated appendicitis in children and the second phase, was the development of the model and internal validation. Finally, a model with values was obtained of performance quite acceptable and a high discriminatory capacity greater than 80%, also, the internal validation showed a good extrapolation of the model to other variables because the optimism was low.
Details
- Language :
- Spanish; Castilian
- Database :
- OpenAIRE
- Journal :
- Blumfield E, Yang D, Grossman J. Scoring system for differentiating perforated and non-perforated pediatric appendicitis. Emerg Radiol. 2017;24(5):547–54., Marzuillo P. Appendicitis in children less than five years old: A challenge for the general practitioner. World J Clin Pediatr. 2015;4(2):19., Jonas CE, Cimino F, Hulsopple C. Cochrane for Clinicians Putting Evidence into Practice Procalcitonin to Guide Antibiotic Therapy in Acute Respiratory Infections Clinical Question Can using procalcitonin levels help guide antibi-otic stewardship for patients with acute respira-tory infec. Am Fam Physician [Internet]. 2018;98(1):25–33. DOI: 10.1016/S0002-838X(18)30204-1., Rentea RM, Peter SDS, Snyder CL. Pediatric appendicitis: state of the art review. Pediatr Surg Int. 2017;33(3):269–83., Newman KD. When Appendicitis Is Suspected in OBJECTIVES. Radiographics. 2001;5056:247–62., Low ZX, Bonney GK, So JBY, Loh DL, Ng JJ. Laparoscopic versus open appendectomy in pediatric patients with complicated appendicitis: a meta-analysis. Surg Endosc [Internet]. 2019;0(0):0. DOI: 10.1007/s00464-019-06709-x, American College of Radiology Suspected Physical Abuse – Child. 2016;1–15., Peter SDS, Sharp SW, Holcomb GW, Ostlie DJ. An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. J Pediatr Surg [Internet]. 2008;43(12):2242–5. DOI: 10.1016/j.jpedsurg.2008.08.051, Buckius MT, McGrath B, Monk J, Grim R, Bell T, Ahuja V. Changing epidemiology of acute appendicitis in the United States: Study period 1993-2008. J Surg Res [Internet]. 2012;175(2):185–90. DOI: 10.1016/j.jss.2011.07.017, Min. Salud MDSYPS. Análisis de Situación de Salud de Poblaciones Diferenciales Relevantes Ministerio de Salud y Protección Social Dirección de Epidemiología y Demografía Grupo ASIS. 2013;1–87., Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: Modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015;386(10000):1278–87., Li HM, Yeh LR, Huang YK, Hsieh MY, Yu KH, Kuo CF. Familial Risk of Appendicitis: A Nationwide Population Study. J Pediatr [Internet]. 2018;203:330-335.e3. DOI: 10.1016/j.jpeds.2018.07.071, Benabbas R, Hanna M, Shah J, Sinert R. Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point-of-care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta-analysis. Acad Emerg Med. 2017;24(5):523–51., Dahabreh IJ, Adam GP, Halladay CW, Steele DW, Daiello LA, Wieland LS, et al. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis. Diagnosis Right Low Quadr Pain Suspected Acute Append [Internet]. 2015;(157). PMID: 27054223 NBK355441., Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen J. Discriminative Accuracy of Novel and Traditional Biomarkers in Children with Suspected Appendicitis Adjusted for Duration of Abdominal Pain. 2009;377(2):364–77., Riaz N, Wolden SL, Gelblum DY, Eric J. Discovery and validation of urine markers of acute pediatric appendicitis using high-Accuracy mass spectrometry. 2016;118(24):6072–8. DOI: 10.1016/j.annemergmed.2009.04.020., Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen J. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. 2009;377(2):364–77. DOI: 10.1038/mi.2008.13., Groselj-Grenc M, Repse S, Dolenc-Strazar Z, Hojker S, Derganc M. Interleukin-6 and lipopolysaccharide-binding protein in acute appendicitis in children. Scand J Clin Lab Invest. 2007;67(2):197–206., Rivera-Chavez FA, Peters-Hybki DL, Barber RC, Lindberg GM, Jialal I, Munford RS, et al. Innate immunity genes influence the severity of acute appendicitis. Ann Surg. 2004;240(2):269–77., Andersson REB. Meta-analysis of the clinical and laboratory diagnosis of appendicitis. Br J Surg. 2004;91(1):28–37., Ebell MH, Shinholser J. What are the most clinically useful cutoffs for the alvarado and pediatric appendicitis scores? a systematic review. Ann Emerg Med [Internet]. 2014;64(4):365-372.e2. DOI: 10.1016/j.annemergmed.2014.02.025., Z. P, S. R, I. M, I. J. Prospective validation of Alvarado score and pediatric appendicitis score for the diagnosis of acute appendicitis in children. Pediatr Emerg Care [Internet]. 2015;31(3):164–8. DOI: 10.1097/PEC.0000000000000375, Khanafer I, Martin DA, Mitra TP, Eccles R, Brindle ME, Nettel-Aguirre A, et al. Test characteristics of common appendicitis scores with and without laboratory investigations: A prospective observational study. BMC Pediatr [Internet]. 2016;16(1):1–8. DOI: 10.1186/s12887-016-0687-6., Andersson M, Andersson RE. The appendicitis inflammatory response score: A tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008;32(8):1843–9., Castro SMMD, Ünlü Ç, Steller EP, Van Wagensveld BA, Vrouenraets BC. Evaluation of the appendicitis inflammatory response score for patients with acute appendicitis. World J Surg. 2012;36(7):1540–5., Adibe OO, Muensterer OJ, Georgeson KE, Harmon CM. Severity of appendicitis correlates with the pediatric appendicitis score. Pediatr Surg Int. 2011;27(6):655–8., Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002;37(6):877–81., Alvarado A. A Practical Score for the Early Diagnosis of Acute Appendicitis. Ann Emerg Med. 1986;15(5):557–64., Florence M, Flum DR, Jurkovich GJ, Lin P, Steele SR, Symons RG, et al. Negative appendectomy and imaging accuracy in the washington state surgical care and outcomes assessment program. Ann Surg. 2008;248(4):557–62., S.J. D, A. K. Point-of-Care Ultrasound Integrated Into a Staged Diagnostic Algorithm for Pediatric Appendicitis. Pediatr Emerg Care [Internet]. 2016;00(00):1–7. DOI: 10.1097%2FPEC.0000000000000773., Depinet H, von Allmen D, Towbin A, Hornung R, Ho M, Alessandrini E. Risk Stratification to Decrease Unnecessary Diagnostic Imaging for Acute Appendicitis. Pediatrics. 2016;138(3):e20154031–e20154031., Elikashvili I, Tay ET, Tsung JW. The effect of point-of-care ultrasonography on emergency department length of stay and computed tomography utilization in children with suspected appendicitis. Acad Emerg Med. 2014;21(2):163–70., Kearl YL, Claudius I, Behar S, Cooper J, Dollbaum R, Hardasmalani M, et al. Accuracy of Magnetic Resonance Imaging and Ultrasound for Appendicitis in Diagnostic and Nondiagnostic Studies. Acad Emerg Med. 2016;23(2):179–85, Rentea RM, St. Peter SD. Contemporary Management of Appendicitis in Children. Adv Pediatr [Internet]. 2017;64(1):225–51. DOI: 10.1016/j.yapd.2017.03.008., Mandeville K, Monuteaux M, Pottker T, Bulloch B. Effects of timing to diagnosis and appendectomy in pediatric appendicitis. Pediatr Emerg Care. 2015;31(11):753–8., Emily S, Elkady S, Shbat L, Youssef F, Baird R, Laberge J M, Shaw K. Determinants of postoperative abscess occurrence and percutaneous drainage in children with perforated appendicitis. Pediatric surgery international. 2014; 30(12), 1265-1271., Fraser JD, Aguayo P, Sharp S W, Snyder C L, Holcomb III GW, Ostlie DJ, Peter S. Physiologic predictors of postoperative abscess in children with perforated appendicitis: subset analysis from a prospective randomized trial. Surgery. 2010;147(5), 729-732., Frongia G, Mehrabi A, Ziebell L, Schenk JP, Günther P. Predicting postoperative complications after pediatric perforated appendicitis. Journal of Investigative Surgery. 2016; 29(4), 185-194., Henry MC, Walker A, Silverman BL, Gollin G, Islam S, Sylvester K, Moss RL. Risk factors for the development of abdominal abscess following operation for perforated appendicitis in children: a multicenter case-control study. Archives of surgery.2007;142(3), 236-241., Lodwick DL, Cooper JN, Kenney B, Deans KJ, Minneci P C, Thakkar RK. Lymphocyte depression as a predictor of postoperative intraabdominal abscess after appendectomy in children. Journal of pediatric surgery.2017;52(1), 93-97, Pathak IS, Sayed IA, Wise L, Sippel M, Hernandez LL, Mulla ZD. Predictors of a Prolonged Length of Stay in Children with Perforated Appendicitis. Southern medical journal. 2016;109(4), 230-235., Simundi c A-M. Measures of diagnostic accuracy: basic definitions. Med Biol Sci 2008;22:61-5., Steyerberg, E. W. Clinical prediction models. 2019. Springer International Publishing., Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
- Accession number :
- edsair.doi.dedup.....7e77beb195a406479c5047c8638e2485