Back to Search
Start Over
Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats
- Source :
- Journal of dietary supplements. 15(3)
- Publication Year :
- 2017
-
Abstract
- Parquetina nigrescens is commonly used to treat diseases in humans and animals in developing countries, including Nigeria. This study evaluates the effects of its polyphenol-rich fraction (prf) on dichlorvos-induced cardio- and renal toxicity. There were several factors assessed during this study, including cardiac and renal markers, serum myeloperoxidase and xanthine oxidase, and electrocardiograph (ECG) changes. The changes in electrocardiograph (ECG) were recorded. Immunohistochemistry of cardiac and renal p38 and nitrotyrosine was determined. Dichlorvos exposure caused a significant decrease in L-glutathione (reduced glutathione) and other antioxidant enzymes with increases in malondialdehyde, myeloperoxidase, advanced oxidation protein products, and protein carbonyl levels. It also brought about alterations in microanatomy of the heart and kidneys accompanied by increases in serum creatinine and urea levels. Exposure to dichlorvos induced prolonged QRS interval and shortened QT durations in rats. Immunohistochemistry revealed lower expressions of cardiac nitrotyrosine and renal p38 (mitogen-activated protein kinase; MAPK) in rats treated with prf of P. nigrescens. Combining all, prf of P. nigrescens demonstrated antioxidant as well as protective properties in the heart and kidneys of rats exposed to dichlorvos. It ameliorated dichlorvos-induced cardio- and nephrotoxicity giving credence to its use in ethnomedicine.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Insecticides
p38 mitogen-activated protein kinases
Heart Ventricles
Administration, Oral
Nigeria
Kidney
Protective Agents
p38 Mitogen-Activated Protein Kinases
03 medical and health sciences
chemistry.chemical_compound
Random Allocation
0302 clinical medicine
Organophosphate Poisoning
Internal medicine
Dichlorvos
medicine
Ventricular Dysfunction
Animals
Pharmacology (medical)
Renal Insufficiency
Rats, Wistar
Xanthine oxidase
Creatinine
Nutrition and Dietetics
Plant Extracts
Nitrotyrosine
food and beverages
Cryptolepis
Polyphenols
Glutathione
Plant Components, Aerial
digestive system diseases
030104 developmental biology
Endocrinology
chemistry
Polyphenol
Toxicity
Dietary Supplements
Tyrosine
030217 neurology & neurosurgery
Biomarkers
Food Science
Subjects
Details
- ISSN :
- 1939022X
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of dietary supplements
- Accession number :
- edsair.doi.dedup.....7e9e6c839b80646bcb3f6e107baff7e5