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Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia
- Source :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2009
-
Abstract
- Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:23:52Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:40:56Z : No. of bitstreams: 1 2-s2.0-68949105928.pdf: 253837 bytes, checksum: 6b23c84fb6e15ab56cd90e38026a074a (MD5) Made available in DSpace on 2014-05-27T11:23:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-01 The potential for malignant transformation of oral lichen planus is still controversial. The expression of proteins related to cell proliferation and apoptosis in oral lichen planus and epithelial dysplasia was analyzed to evaluate the true potential for malignant transformation of this disease. Twenty-four cases of each lesion were subjected to the streptoavidin-biotin technique for identifying the immunohistochemical expression of PCNA, p53, bax, and bcl-2 proteins. Of the 24 cases of oral lichen planus, 14 (58.33%) were positive for PCNA, 10 (41.67%) for p53, 4 (16.67%) for bcl-2 and 12 (50%) for bax, whereas of the 24 cases of epithelial dysplasia, 20 (83.33%) were positive for PCNA, 10 (41.67%) for p53, 6 (25%) for bcl-2, and 20 (83.33%) for bax. Chi-squared test showed no statistically significant differences between the expression of p53 and bcl-2 in oral lichen planus and epithelial dysplasia, regardless of the grade (P > 0.05). However, the expression of PCNA and bax was significantly increased in epithelial dysplasia (P < 0.05). The results of this study showed that alterations in expression of these proteins are observed in oral lichen planus and epithelial dysplasia, suggesting the potential for malignant transformation in both lesions.
- Subjects :
- coloring agent
diagnostic agent
squamous cell carcinoma
Epithelial dysplasia
Pathology
medicine.medical_specialty
protein bcl 2
cycline
precancer
protein p53
Palatine Tonsil
cell transformation
Apoptosis
Malignant transformation
Bcl-2-associated X protein
stomatognathic system
Proliferating Cell Nuclear Antigen
Carcinoma
medicine
mouth tumor
Humans
BAX protein, human
human
Oral mucosa
skin and connective tissue diseases
Coloring Agents
General Dentistry
Cell Proliferation
bcl-2-Associated X Protein
Mouth neoplasm
integumentary system
biology
lichen planus
medicine.disease
Immunohistochemistry
Proliferating cell nuclear antigen
stomatognathic diseases
medicine.anatomical_structure
Cell Transformation, Neoplastic
Proto-Oncogene Proteins c-bcl-2
biology.protein
Carcinoma, Squamous Cell
Oral lichen planus
pathology
Mouth Neoplasms
Tumor Suppressor Protein p53
Precancerous Conditions
protein Bax
Lichen Planus, Oral
Subjects
Details
- ISSN :
- 13434934
- Volume :
- 51
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of oral science
- Accession number :
- edsair.doi.dedup.....7ea4a60ace946739541c522b2c4c1dd3