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New cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin: preparation and its application in molecular binding and recognition

Authors :
Huacheng Zhang
Jian Shen
Ming Gang Zhao
Yan Bai
Jian Ye Li
Ai You Hao
Hong Yuan Sun
Gui Ying Xu
Tao Sun
Source :
Carbohydrate research. 344(15)
Publication Year :
2009

Abstract

A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin (6-HB-beta-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of beta-cyclodextrin (beta-CD), 2-O-(2-hydroxypropyl)-beta-cyclodextrin (2-HP-beta-CD), 6-O-(2-hydroxypropyl)-beta-cyclodextrin (6-HP-beta-CD), and 2-O-(2-hydroxybutyl)-beta-cyclodextrin (2-HB-beta-CD). The relationship between the complex stability constants and the possible structures of inclusion compounds was discussed with the interaction of hosts and guests, including the weak hydrophobic interactions, the size/shape matching, the steric hindrance, and the hydrophilic property.

Details

ISSN :
1873426X
Volume :
344
Issue :
15
Database :
OpenAIRE
Journal :
Carbohydrate research
Accession number :
edsair.doi.dedup.....7ea51d7fdad721da901a799621e965c1